Hi Everyone, I am new to the forum. My first episode was in 1975 with Optic Neuritis, but I was not diagnosed until 1993 with RRMS. Until about 5 years ago, I did not have any significant disability, but have progressed to SPMS, so no relapses, only progression. I have never taken any meds, and have only relied on diet until now. I was accepted in the Tcelna study, and had the first infusion in August, and have had 4 so far. Next appt. is scheduled for early February. So far improvements, and no reaction to the infusions, I feel like I am either getting the placebo, or it is just not working. Visually all infusions have been clear. I have continued to progress, my as walking continues to decline, as well as bladder and bowel issues..