NHE wrote:One of the autoantigens used by Opexa to separate out myelin reactive T cells is myelin oligodendrocyte glycoprotein, also known as MOG. I'm not 100% certain, but I believe that this protein is specific to oligodendrocytes as compared to schwann cells. As oligondendrocytes are only found in the central nervous system (CNS) and not the peripheral nervous system, the use of MOG should help to isolate T cells which are targeting myelin in the CNS.
Despite the long-standing assumption that MOG was the only CNS specific myelin protein, MOG mRNA expression was recently demonstrated in peripheral myelin although protein expression was not detected (Pagany et al., 2003).
Lyon wrote: I don't blame you although once you've produced the specific type of MRTC's they were looking for I was under the assumption that you were in like flint (even though I'm not sure what that saying really means?)
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