Since your trial only lasted a year, I was thinking that you might have asked your own neuro to give you an MRI once the trial was over. I know I would be dying of curiosity if I still hadn’t had a look at my MRIs after all these years
I went into an extension study about 12 months ago. So, I was part of the dose escalation and safety study for 3 years. I never did a personal MRI during that time.
I have MRI film from when I was diagnosed, but that predates being in the study by a couple of years. Since I do not have a baseline MRI from just before starting the study, getting an MRI done now and comparing it to film that predates the study by more than 2 years would not be a worthwhile comparison. I am sure there was significant damage done during those 2 years.
Anyone who is accepted into the next study or anyone in the current study who thinks they are in the placebo group might ask their neurologist to order an MRI. They would have that for comparison in the future.
I think it is not until after the third treatment that the average patient’s immune response is at a protective level. It may be at that point you would want to have an MRI done for future reference, or maybe after the fifth treatment.
I think Opexa is having quite a few MRIs done, so maybe it is yet to be determined as to when the best time to get a personal MRI for future comparison, and this would be different from one patient to the next.
Any MRIs that are done for comparison should be done on the same machine, and whom do you get to do the comparison in the future? It would be nice to have a baseline MRI from just before my first treatment, but I am not sure if I would do anything with it.
My issue is further complicated by the fact that I was in the low-dose group for at least a year before moving into the mid-dose, which is the current study dose. The low-dose was not sufficient to bring the number of MRTCs down to zero or near zero, so there may have been some more damage done before I moved into the mid-dose. I was improving while on the low-dose, but the MRIs might have shown some activity.
I guess I have just answered this question for myself. In my case, it seems too complicated to have privately analyzed changes in my MRIs from the beginning of the study until now. Maybe after Tovaxin is approved, I can find out about any changes.
Ignorance may be bliss. I am feeling fine. If my MRIs showed something different, that might have a suggestive effect.
I think it is about time for Bob to post a picture of Homer Simpson’s brain, and make a comment that my brain is too small of a target to be attacked. d’oh