havingms wrote:I have seen increased spasticity too.
my Doc. thinks it is from what he calls old injury from the last flare up and not a new relapse.
I may be experiencing a stop in progression but just had more behind the scenes damage that shows up when I get hot.
That's good to hear Heather!akaheather wrote: P.S. I do still believe in this drug and for the record I'm not dropping out.
Hi havingms,havingms wrote:Dear Loobie,
Ditto! I second all that you have said. Our experiences sound almost identical. Cant wait for the fall.
Have any of these recent symptoms lasted more than four days?
Hi Heather,akaheather wrote:I did call my neuro's office today to report my new "symptoms". The nurse I talked to seemed to think it sounded like an old injury exacerbated by heat and fatigue.
and MS affects parts of the brain I'd never heard before and hadn't previously imaginedNeuropathologic studies of GM involvement.
Although MS is generally considered a disease of
WM, pathology can also be found in the deep cerebral
nuclei2,4 and cerebral cortex.2,5-10 Cortical MS
plaques may be abundant in some patients with MS
I guess my point is that even if you were on the real thing and the disease process is stopped or stopping, things might be a lot more complicated than I originally thought and who knows how long things like what you mention might pop up from stress, heat, etc..?? Maybe always.Atrophy of the deep gray nuclei also occurs
in MS and is disproportionate to the amount of
global atrophy.23,29 Volume loss of the thalamus4,29
and the caudate nucleus23 has been documented using
MRI segmentation (figure 5). In the thalamus,
there is substantial neuronal loss, depletion of neuronal
metabolites, and a 22% loss of neuronal density.
4 These observations are consistent with PET data
demonstrating hypometabolism of the brain affecting
cortical and subcortical GM more than WM.30
With use of voxel-based morphometry (VBM) from
MRI scans, a recent study31 of 51 patients with
RRMS and 34 control subjects showed that GM volume
was significantly decreased in the frontotemporal
cortex, precuneus, anterior cingulate gyrus,
postcentral gyrus, and caudate nuclei bilaterally.
These results suggest that in RRMS, GM reduction
preferentially involves frontotemporal and deep central
GM. Another VBM study also reported significant
volume reduction in temporal and prefrontal
cortex.32 VBM will likely emerge as an important tool
in understanding the topography, time course, and
clinical relevance of GM involvement in MS.
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