There is obviously a lot more to learn about the different forms of MS. Besides no longer having the remission phase of RRMS there may be some other mechanics at work with SPMS. The majority of research has been done trying to understand the hows and whys of RRMS. PPMS and PRMS (primary relapsing MS) seem to be very different than the other forms of MS.
I have focused my attention on RRMS and have not read much about the assumed mechanics of SPMS, PPMS, or PRMS. I probably should spend some time studying the other forms, because I seem to have had a fairly aggressive form of MS. I have the diagnosis of RRMS, but it was thought that I had possibly transitioned into SPMS almost immediately. I had several attacks in rapid succession with no apparent remission. My blood profile is mainly CD-4 WBCs but I did have some CD-8 WBCs.
When I was moved into the mid-dose group, my MRTCs dropped to zero. Because I have a line of WBCs that are associated with PPMS, it seems probable that Tovaxin will work for PPMS, but since it is quite different, you may need to do more than eliminate the MRTCs.
My study recruited both RRMS and SPMS. I don't know how many were of each type, but the 92% reduction in attacks was for all patients. This would indicate that Tovaxin must work for SPMS. Also if it is true that I had already transitioned into SPMS, that adds a little more credence to the hope that Tovaxin will work for SPMS.
Every answer generates 10 more questions. I have many unanswered questions. I hope that this study will answer some of them.
My brothers have updated my site http://ihavems.com/
with a section of 20+ FAQs on MRTCs. They also added a few new pictures to my timeline followed by this statement.
April 2006 You have probably realized from the last few entries that Tim is doing fine, and we don't have anything to report. We are going to stop adding anything to Tim's timeline. There are many people who are now enrolled in the Tovaxin study. It is their turn to tell us their stories. Some will have great success like Tim and post up the good news. Others may not fare as well. They may be in the placebo group, but we will never know. We hope the vast majority will stop having attacks and regain some of their lost function. We assume that we will probably never hear their stories. We will close Tim's timeline with a quote by Tiny Tim from A Christmas Carol. Our Dad uses this quote to end the annual Christmas letter every year.
And Tiny Tim adds a wiser corollary to his father's toast, God bless us every one!
I hope to read lots of interesting stories posted on the web, but for me, I will quote that great orator, Porky Pig, "Th-th-th-that's all folks!"