Progressive Multifocal Leukoencephalopathy(PML) info
New research article for May 2005 release describes full recovery of PML after removal of immune suppression. I think immune monitoring can remove PML cases from occurring.
Am J Transplant. 2005 May,5
Successful outcome of progressive multifocal leukoencephalopathy in a renal transplant patient.
Crowder CD, Gyure KA, Drachenberg CB, Werner J, Morales RE, Hirsch HH, Ramos E.
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
We report the case of a 47-year-old man who developed progressive multifocal leukoencephalopathy (PML) after receiving immuno-suppressive therapy for renal transplantation. The patient presented with a focal seizure and cognitive changes 5 months post-transplantation. He was found to have enhancing lesions in the parietal lobe and typical findings of PML in a brain biopsy.
Immunosuppression was discontinued and the neurological symptoms gradually resolved over a period of 4 weeks. The patient is free of any neurological symptoms 36 months after the diagnosis of PML and imaging studies demonstrate resolution of the PML lesions. The patient returned to hemodialysis 3 months after immunosuppression was discontinued. We also present a review of the literature on PML in renal transplant recipients.
http://www.ncbi.nlm.nih.gov/entrez/quer ... s=15816900