I don't understand what that means?
Although noted that it's been done on veins in end stage diabetes I've yet to find that venous angioplasty has been done with any regularity in comparable situations in the past so, although I would expect the risk to be minimal, it hasn't actually been shown yet.
gymbuff wrote:Sorry to go back to this issue again but am I being naive in thinking that blood tests and meeting the doctor/neurology team every 4 weks is some sort of protection against PML. Surely if the signs and symptoms are spotted early enough death or serious health deterioration can be mitigated or eliminated.
Can anybody please shed some light on the issue for me.
I personally feel that Tysabri is a huge improvement for some people over the CRABS but accepting Tysabri use does require accepting considerable risks. Additionally the degree of risk has shown to increase depending on location and with increasing time that you are on Tysabri.
With the current alternatives in mind I consider myself a Tysabri proponent but, considering the increasing risks, three years is a long time to be on Tysabri uninterrupted in addition to problems with PML being more likely in Europe.
The patient who died was a United States patient who had received 14 monthly infusions of Tysabri as a stand-alone treatment.
They [Biogen] went further to suggest that in their tests on the general population, the JC Virus is 50 -60% prevalent vs. the 90-95% generally accepted.
Of course one has to keep in mind that Biogen has an interest to make Tysabri/PML/JCV look as harmless as possible.
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