NEJM articles and editorial

A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

NEJM articles and editorial

Postby Arcee » Thu Jul 28, 2005 5:43 am

Hi Everyone -

Thought I would point out that the New England Journal of Medicine out today has three articles following up on Tysabri and PML along with an editorial. I only get the abstracts and can't really tell what the key points are, but maybe one of you has better access or better insight into what is written.

- Arcee[/i]
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Postby OddDuck » Thu Jul 28, 2005 11:06 am

Arcee,

Yes, altogether there are these articles that were due to be published in the NEJM on July 28th (today). Two of these (below) I found and posted links to in the other thread of mine on here. If you notice, now that the NEJM has been released, even those links to the articles I previously posted no longer work (darn it, I wish I would have printed those!) Anyway, altogether, there are the following articles that we'll now need to "purchase" or obtain from someone who receives the NEJM in the mail.

4: Adelman B, Sandrock A, Panzara MA.
Natalizumab and Progressive Multifocal Leukoencephalopathy.
N Engl J Med. 2005 Jun 9; [Epub ahead of print]
PMID: 15947083 [PubMed - as supplied by publisher]

5: Berger JR, Koralnik IJ.
Progressive Multifocal Leukoencephalopathy and Natalizumab -- Unforeseen Consequences.
N Engl J Med. 2005 Jun 9; [Epub ahead of print]
PMID: 15947082 [PubMed - as supplied by publisher]

6: Van Assche G, Van Ranst M, Sciot R, Dubois B, Vermeire S, Noman M, Verbeeck J, Geboes K, Robberecht W, Rutgeerts P.
Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn's Disease.
N Engl J Med. 2005 Jun 9; [Epub ahead of print]
PMID: 15947080 [PubMed - as supplied by publisher]

7: Kleinschmidt-Demasters BK, Tyler KL.
Progressive Multifocal Leukoencephalopathy Complicating Treatment with Natalizumab and Interferon Beta-1a for Multiple Sclerosis.
N Engl J Med. 2005 Jun 9; [Epub ahead of print]
PMID: 15947079 [PubMed - as supplied by publisher]

8: Langer-Gould A, Atlas SW, Bollen AW, Pelletier D.
Progressive Multifocal Leukoencephalopathy in a Patient Treated with Natalizumab.
N Engl J Med. 2005 Jun 13; [Epub ahead of print]
PMID: 15947078 [PubMed - as supplied by publish
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Postby OddDuck » Thu Jul 28, 2005 11:30 am

Ok.........here is an "editorial" based on this person's review of the reports from the Tysabri investigations.

http://www.acnr.co.uk/pdfs/volume5issue ... eviews.pdf

It starts on page three. It's short, but might be interesting to some.

Deb
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Postby HarryZ » Fri Jul 29, 2005 8:38 am

Deb,

Thanks for posting that link. It sure makes you wonder just what else isn't being made available by Biogen in all of this. And like some of us have said in the past, the proper research with Tysabri simply wasn't done. How sad for MS patients everywhere!

Harry
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