I've been on Tysabri for a few years now, and while I understand your concerns, I have had no problems. No miracle cure for me, But Copaxone stopped working for me, so then they had just taken Tysabri off the market at that time,They put me on Rebif while I waited. Rebif made me sick at first and it didn't help . now I've been on it. For me, it's like not taking a med for your MS because you go once a month, the nurse does the infusion, I watch TV then I go home. I wish you the best of luck and God Bless.