I have been on Tysabri for over 3 years, having my 45th infusion next week. Recently I noticed serious weakness from the knees down. I had serious difficulty walking a few times. I have had no other problems during this period of weakness. Bladder and eyesight are great, no tingling or anything else just the weakness at the knees.
Has anyone else had this problem? Is it just the "normal" course of MS or has anyone suggestions on how to counteract it. Appreciate any suggestions