33 deaths due to PML

A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

33 deaths due to PML

Postby RuSmolikova » Sat Oct 15, 2011 12:16 pm

MS patients on Tysabri: 170 PML cases, 33 deaths already (as of 4-th of October 2011).
"...as of the end of September 2011 approximately 63,500 patients were on commercial and clinical TYSABRI therapy worldwide. And that cumulatively approximately 92,200 patients have ever been treated with TYSABRI in the post-marketing setting," said Biogen Idec.
Last edited by RuSmolikova on Fri Oct 28, 2011 10:35 am, edited 1 time in total.
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Re: 33 deaths due to PML

Postby Smilingface » Sun Oct 16, 2011 6:23 am

Does anyone know how many total number of patients on Tysabri as of Oct 4?
Primary Progressive, Onset 10 years ago at age 42, diagnosis 6 years ago, Vit D, Chinese Herbs, Exercise, yoga. So far tried antibiotics, fumaric acid and 4AP. Currently participant in the FTY720/PPMS Trial.<br />
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Re: 33 deaths due to PML

Postby HarryZ » Sun Oct 16, 2011 6:57 am

Smilingface wrote:Does anyone know how many total number of patients on Tysabri as of Oct 4?


This link will give you some numbers as of Sept 16. Obtaining a number of patients currently on the medication is kind of difficult since it changes constantly as people stop using the drug and others start.

http://www.jwlindseymd.com/id66.html

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Re: 33 deaths due to PML

Postby Bender » Sun Oct 16, 2011 9:45 pm

from link

There are about 46,000 people on Tysabri in the US
and that was 9/16

I'm thinking 33% over 46k doesn't seem horrible. But I won't deny that on some level the PML thing gives me pause.
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Re: 33 deaths due to PML

Postby RuSmolikova » Fri Oct 28, 2011 10:33 am

Smilingface wrote:Does anyone know how many total number of patients on Tysabri as of Oct 4?


Biogen Idec announced today:
"...as of the end of September 2011, we estimate that approximately 63,500 patients were on commercial and clinical TYSABRI therapy worldwide, and that cumulatively approximately 92,200 patients have ever been treated with TYSABRI in the post-marketing setting."
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Re: 33 deaths due to PML

Postby HarryZ » Fri Oct 28, 2011 10:46 am

Biogen Idec announced today:
"...as of the end of September 2011, we estimate that approximately 63,500 patients were on commercial and clinical TYSABRI therapy worldwide, and that cumulatively approximately 92,200 patients have ever been treated with TYSABRI in the post-marketing setting."


Which means 31% of those who have tried the drug have discontinued it for various reasons. For a medication that Biogen told us from clinical trials, there was a 67% reduced risk of relapse...hmmm.

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