PML associated with natalizumab in paediatric MS

A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

PML associated with natalizumab in paediatric MS

Postby MSUK » Mon Oct 31, 2011 12:03 am


Background: In the pediatric Multiple Sclerosis (MS) population large and controlled studies on safety and efficacy of Natalizumab have not yet been performed. In literature there have been no cases of Natalizumab-related Progressive Multifocal Leukoencephalopathy (PML) reported in paediatric population with MS.

Case Report: A 14-year-old girl presented in October 2009 diplopia, gait ataxia, vomiting and impaired mentation, preceded by asthenia, fever and left sensory loss lasting for 3 days, 1 month earlier. MRI showed a diffuse leukoencephalopathy with large lesions in brainstem, semioval centers and spinal cord with diffuse gadolinium enhancement. The IgG Index was increased. After treatment with i.v. Methylprednisolone (MP) she improved.... Read More - ... ageid/1408
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Re: PML associated with natalizumab in paediatric MS

Postby HarryZ » Mon Oct 31, 2011 6:08 am

Remember when MS was unheard of in children. That has now certainly changed with a Children's MS Clinic opened at St. Michael's Hospital in Toronto. What could possibly be causing this disease to appear more and more in kids? I'm leaning towards diet but who knows.

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