This Is MS Multiple Sclerosis Community: Knowledge & Support

Just curious if anyone has gone through the things I have. Started Tysabri 2 months ago so, 2 infusions. I have not stopped vomiting and having diarreah since then. Terrible stomach pain and constant nausea. My Neuros seem a bit lost and only hear that I possibly developed an antibody to Tysabri. I have researched a ton and have not found any similar long term issues. They suspended my infusions immediately and I have been tested forwards and backwards for another cause. There isnt one! Thoughts?
Be well,
Lars

Hi Lars---
saw your name on the feed and wanted to check in. not glad to see this.
Liver injury problems are attributed to Tysabri, and can cause nausea, vomiting, etc.

http://www.nationalmssociety.org/about- ... index.aspx
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000289/

you are not alone.
http://healthquestions.medhelp.org/tysabri-nausea

If your liver enzymes are high (and even if they don't show up on AST/ALT tests) maybe talk to your doctor about beginning milk thistle (silymarin) supplements. It might also just be a bad flu? Whatever it is...sending good thoughts.
take care, Lars.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Hi Cheer!
I wish it were the flu. It has been over 2 months now and started literally the second I walked out of the infusion center the first time. I have been tested forwards and backwards. We keep coming back to antibodies developed against Tysabri. As of now, liver panels seem fine. Just longing for the wash out at this point.
Take Care,
Lars

OK. feel bad for you, Lars--here's maybe what your neuro was referring to--"persistant antibody positivity"--which increases hypersensitivity reactions, including vomiting and nausea. I guess the antibody test is the only way to know for sure.
Hoping your symptoms subside, now that you've stopped infusions.

http://www.drugs.com/uk/tysabri-300-mg- ... -7344.html

maybe someone else who's gone through this will pipe in and offer support...
Take it easy.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Thank you Cheer. Doesnt seem to be much doubt at this point.

Hey there, Lars

I, too, have been sick since the day after my latest infusion, from November. Nausea, no appetite, vomiting, fever, lung infection which caused onset of Asthma (!!), weakness, dizziness, upper-abdominal cramping, and a really intense set of hives all over my arms, neck and face.
All of my tests for 'other things" are coming back normal, and I'm also waiting for an antibodies test to come back. And two other patients who received the same batch of tysabri at my infusion center are sick with severe allergic reactions, as well.

Wonder if something bigger is happening, with the drug. Either way, I'm sick, sick of being sick, I'm frustrated, and not looking forward to the "tysabri relapse," now that I've been taken off it.

Wishing you, and me, and everyone experiencing this currently, the best!
happy holidays