pballer76 wrote:I am JCV+. I used tysabri 73 times. I switched to tecfidera, used it for 4 months.
My neuro had me stop taking it. I had 1 flare and developed psoriasis while on tecfidera.
I want to get back on tysabri. I did the index blood test and I am a .46.
Does anyone know what this means? I want to know what my risk of PML is.
I have used Avonex, Rebif, Tysabri, and Tecfidera.
cheerleader wrote:The antibody index blood test for you is .46--if you had no prior drug treatment and used Tysabri for less than 2 years, your accessed risk for PML would be 5 in 1,000.
But the fact that you have used other meds, and used Tysabri for longer, there is "insufficient data" available about your risk.
Know that it is higher than 1 in 89.
centenarian100 wrote:I'm not exactly sure from where you are getting this figure (1/89). The data in the article don't go past 72 months, but placing the opening poster in the 48-72 month category without a history of immunosuppression with an antibody index <0.9, the risk is estimated to be 0.4 per thousand.er in the 48-72 month category without a history of immunosuppression with an antibody index <0.9, the risk is estimated to be 0.4 per thousand.
cheerleader wrote:Please note that it shows that in the 48-72 month category with prior IS usage the risk is unknown, due to insufficient data-- but it would be greater than 1 in 89, which is the risk for the 25-48 month group. I was considering Tecfidera to be prior IS, but if it is not---the risk rate for PML in a JCV+ individual is 1 in 164. Apologies for confusion.
centenarian100 wrote:HarryZ wrote:I don't think the word "trust" and "Biogen" belong in the same sentence.
haha...perhaps not. I don't think I would give Novartis or Teva much trust either for what it's worth.
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