I had been recently diagnosed as a case of Multiple sclerosis with active inflammation and had my first attack a month ago. Intravenous steroids were given and am currently on Oral steroids for tapering dosage. I had paraesthesias and visual symptoms in right eye, but after steroid therapy, currently i dont have any symptoms except for Urgency and frequency of urination, no incontinence though. My Neurologist after reviewing my clinical profile and MRI progression of lesions opined that I should be started on Natalizumab as a first line treatment for 2 years followed by switch over to other medications. However I couldn't decide whether to start with the third line of drugs straight away nor could find any inputs from the people who were started likewise.
Can anyone who is also on similar treatment with Natalizumab as a first line treatment as opposed to other first line drugs share their experience?
Can anyone please tell me if you dont mind what were your presenting symptoms and the rationale your neurologist discussed to start on Tysabri straight away instead of other treatments?
And another major concern to me is if required in future if I need to be put back on Tysabri after the switch over, wont it actually increase my risk of PML? and was it discussed with you whether starting straight away on Tysabri, exhaust options for next line of managements in the long term future or not?
Thank you in advance for that.