After I had my 27th infusion yesterday I talked to my neuro about what to do after Tysabri. His recommendation was not to take any other CRABS and see how things are going. If another relapse occured her would advice me to take an interferon (I already tried COP prior to Tysabri with limited success).
In his opinion, getting back on to Tysabri -even after a break of year or so - would come with unforseeable risks, because there is no data available that shows how the immunesystem recovers from Tysabri. While there is a defined "wash out time" for Tysabri, it still remains unclear whether Tysabri did some long term changes to the immunesystem, the BBB or maybe it allowed the JC-virus to evolve to a more dangerous state - in whatsoever way.
Regarding upcomming therapies like Rituxan, Campath or Cladribine my neuro thinks it will be unlikely that after Tysabri (even if there would be a reasonable break period) I would be eligible to get any of them as some sort of "first line" treatment. The only thing that would sound like an option for me in the nearer future might then be BG-12....
Treatment: Gilenya since 01/2011, CCSVI both IJV ballooned 09/2010, Tysabri stopped after 24 Infusions and positive JCV antibody test, after LDN, ABX Wheldon Regime for 1 year.