I also tried Ty when it was on the market the last time, but had terrible side effects the weekend it was taken off the market (lower body paralysis), I'm now getting iTy again! My neuro thought Ty is my best bet right now, even though I had that reaction the first time. I have had 4 infusions this time, and instead of instant paralysis of my legs, it seems to be a slow-onset version. I will do one more infusion. That way I gave Ty a fair chance, but I don't know. I have SPMS, so Ty may just not work for me. Well, that's my story. Otherwise no side effects, not even a headache. Good luck!