I'm new to this site & forum, but I had my 1st Tysabri infusion on Dec. 28 and will have my next one in 2 days (Jan. 28). I've been dx'd since 1997 and am now secondary progressive/worsening RR. I've tried Copaxone, Rebif and 6 doses of Novantrone with little slowing of the progression EXCEPT on MRI (my MRI's are very pretty--no new lesions and the existing ones have faded since the Novantrone). Clinically, however, it's another story. In 7 years I've gone from walking normally to using first a cane, then I aded first one brace and then 2 braces. I use a wheelchair (power) for distances longer than about 20 ft., but use a walker for just around the house or office. I still work fulltime as a secretary, but I do not drive and have had to give up many activities which I have previously enjoyed including cooking, sewing. So I am interested in a slowing of the progression of this MS freight train. My health insurance company said they would initially pay for 3 doses and then my doctor and I would see what comes next. After my 1st dose of Tysabri I noticed 4 different times in the 2 weeks following infusion that I was able to walk a bit better. Not dramatic but better than nothing. I will report back after my next infusion.