If you or anyone has data supporting the 18-month efficacy drop rumour, either in theory or fact, please post it.
And on Cafepharma, its as likely as anywhere to be disinformation by Tysabri competitors.
I wonder how long it will take them to assemble the data, analyze them, get them to the FDA and release it. My guess - end January Press Release. But I hope sooner. I'll certainly be revisiting this thread when those data are released - whether I'm right or wrong.
As for a preview, note that in the 6 month Phase 2 trial there was a 50% reduction in relapses with Tysabri relative to placebo. In the 1-year Phase 3 study, there was a 66% reduction in relapses relative to placebo. I like that direction. Wanna bet that the 2yr data are >70% reduction? I would. Cannot wait. And the EDSS data?
Then there is just as much chance as what these people are talking about is very true!
I know it's easy to build up expectations on something that you hope is going to be very good. But in view of the past record of MS drug research which has been anything but , let's take it one step at a time and wait for the science.
Regarding the 18-month efficacy rumour, and your claim that the supporting data will be given 'in time,' why spread the rumour prior to having the data/proof? Why not wait 'in time' before spreading such nonsense? I just don't understand.
You must be joking! Again, don't spread the rumour unless you can back it up with facts of some kind.
Past MS research has nothing to do with the facts that I presented from the Tysabri P2 and P3 trials. The decrease in relapse rates in the 1 yr trial compared ot the 6 month trial is a fact. One person might want to draw a correlation on that basis, another might not. No right or wrong here, just individual choice. Agree to disagree, and let each reader decide how they feel.
On the one hand, you suggest not building up hopes, but on the other hand you freely dash hopes by quoting an anonymous poster with no data who talks of an 18-month issue. OK to be skeptical, but not OK to be optimistic? Balance?
Harryz, we seldom agree except on the issue that, certainly, more data are needed. I obviously think I'm right, but the issues we are discussing are not black/white and I also recognize (based on my past history) that I could be partially/completely wrong. I'll leave it at that, and give you the last word.
Harryz, how about some GOOD news for once. I'll start it off:
Why are you equating a MS doc, who is speaking to an audience of MS professionals and gave his opinion about Tysabri, as "bad news"?
So despite all the data that has been presented by Biogen, there are MS docs out there that are being cautious about it and hold a "wait and see" attitude. If I had the name of the doc I would gladly post it but it was not mentioned in the note.
I never said it was bad news, I just said how about some good news. I do not understand why you suggest this, but perhaps you should re-read my post. [And please don't put "bad news" in quotes as if I said it - I most certainly did not. Thank you.]
As for the intent of my posts, I simply posted links to articles which named MS Doctors who were upbeat on Tysabri, and willing to use it now. You had posted something about a more cautious Doctor. I thought my posts brought a healthy balance to the discussion. What's wrong with that?
Agree to let the readers decide, but methinks they need to hear both sides of the story.
Lets just hope they get the 2 yr data out quickly. Whatever it says, I'm sure we'll find something to disagree about.
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