I'm trying to remember my first infusion - I also have one scheduled for Thursday afternoon (my 20th). Make sure you use the washroom - its a pain in the butt to bring an IV stand with you...Just relax, they may offer you some benadryl; they'll go through a checklist with you, set you up comfortably in a chair, set up your IV, and check your vitals about 4 times over the next hour. ...You sit for another hour to make sure that you're not having any kind of allergic reaction, and go home! I remember being a little tired after the first one - probably from the stress of worrying about anaphalaxis, but that was it. From infusion 2 on, it becomes very routine and fairly boring - most people go to work after their infusion - I'm actually partial to going to the driving range. From about infusion 5 on - most people don't even wait around for the extra hour - it really becomes very routine. Good luck, and get some rest.