flora, in my research on Biogen, I speculated and said I had seen this "tactic" used many times in business before. It was a quick infusion of cash tactic. (I actually hate being proven correct.........this time.) I've said this before, and I'll say it again. I do this type of research for a living.
lurker: I would beg to differ with your neuro about the macrophages part. You can refer him to my research on VLA-4 antagonists, and which BIOGEN itself
knew, also. I don't care if I'm "right", I'm just respectfully suggesting that if he researches it a little deeper, he'll see that he might have misinterpreted that assumption (that it blocks macrophages). That's how the virus got into the brain in these patients. Via the APC route THROUGH the BBB.
needless to say, this hypothesis makes it seem unlikely that removing avonex from the equation will eliminate the risk
lurker, I have to totally agree. I've been thinking about that a lot all last night (and overnight). Again, I speculated in my previous posts that what I see Tysabri may be better utilized as is a very
short term treatment (just like the steroids are used) (and/or as Novantrone is used) for inflammation. BUT, again, Tysabri will end up having even more restrictions than that in the end. (Just my "guess", of course.)
Well, as better2together is beginning to post, here it comes. The groundwork for "narrowing" down the uses for Tysabri, so it can be placed back on the market. This one I WILL bet you on. I recognize this tactic, also.
Harry has been correct all along, also. I tried to back him up (because I knew he couldn't divulge confidences) by ALL my research I did on Biogen. If anyone wants to truly know what is going on behind the scenes (even just a LITTLE bit, and even that was enough for ME), I refer you again back to the thread I did when I researched Biogen as a company (that I posted in this thread earlier). EDIT: Oh, wait, I see I did NOT post it earlier....it's at: http://www.thisisms.com/modules.php?nam ... iogen+idec
Hey, call me crazy, I'm used to it.
Again, I'm SO sorry, folks. It literally makes me sick.
As for the FDA? Well..............even though I was almost tarred and feathered, I DID write to them, AND they answered (so I have written acknowledgement that they received my "warnings" about Tysabri and Biogen). That is called "gotcha" (speaking in legal terms). So, ptwo, if any news media wants to talk about anything, send them MY way!
EDIT: Besides, there ARE other methods to try to do what it was "touted" that Tysabri was going to do. I'll just leave it at that.
SECOND EDIT: I just wanted to put that sort of "notice to the media" in bold. Just in case. Like ptwo just mentioned, and for which I was tarred and feathered for mentioning previously, also........you just never know who reads our posts.