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cancer drug

Posted: Thu Jul 01, 2010 9:51 am
by scorpion
I am not sure how this differs from drugs like Campath but it sounded fairly interesting...


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Posted: Thu Jul 01, 2010 11:28 am
by AlmostClever
Quote:

"To make this discovery, scientists used two groups of miceā€”the first treated with bortezomib and the second with saline"

Do mice experience placebo? lol

Posted: Thu Jul 01, 2010 3:29 pm
by scorpion
huh?

Posted: Thu Jul 01, 2010 6:02 pm
by patientx
I don't know, but from my limited understanding it sounds pretty similar to Campath. It looks like the difference might be, whereas Campath, Rituxan, and other MABs, are actually antibodies that bind to T and B cells, this drug causes T cell death by inhibiting NF Kappa B activation (whatever that is). I guess the NF Kappa B is involved in activating inflammatory T-cells, so maybe that's how it leaves "good" T-cells unharmed.

Re: cancer drug

Posted: Thu Jul 01, 2010 11:42 pm
by NHE
patientx wrote:I don't know, but from my limited understanding it sounds pretty similar to Campath. It looks like the difference might be, whereas Campath, Rituxan, and other MABs, are actually antibodies that bind to T and B cells, this drug causes T cell death by inhibiting NF Kappa B activation (whatever that is). I guess the NF Kappa B is involved in activating inflammatory T-cells, so maybe that's how it leaves "good" T-cells unharmed.
NF kappa B = Nuclear Factor kappa B. It's a transcription factor. When activated in cells, it goes into the nucleus and turns on the transcription of proinflammatory genes.

Several supplements inhibit NFkB such as EGCG, curcumin, and R-lipoic acid.

NHE

Re: cancer drug

Posted: Fri Jul 02, 2010 8:10 am
by patientx
NHE wrote:Several supplements inhibit NFkB such as EGCG, curcumin, and R-lipoic acid.

NHE
Interesting. Do you have some research that you could point to about these things inhibiting NFkB?

Re: cancer drug

Posted: Fri Jul 02, 2010 9:42 am
by cheerleader
patientx wrote:
NHE wrote:Several supplements inhibit NFkB such as EGCG, curcumin, and R-lipoic acid.

NHE
Interesting. Do you have some research that you could point to about these things inhibiting NFkB?
Jeff's been on EGCG for 3 years. As well as inhibiting NFkB, it is a BBB permeable chelator. Here's a paper on the NFkB affect:
http://jmm.sgmjournals.org/cgi/reprint/56/8/1042.pdf

Check out Charite (Berlin) studies on EGCG in pwMS. Impressive results.
cheer

Posted: Mon Jul 05, 2010 12:06 pm
by Frank
Sorry to hijack the thread, but did the Charite already publish data on the EGCG trial?

Thanks!
--Frank

Re: cancer drug

Posted: Tue Jul 06, 2010 12:45 am
by NHE
Here's an overview of some of the cell signalling pathways involved with NF-kB. More info related to the specific supplements can be found using Pubmed.

NHE


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