cancer drug
Posted: Thu Jul 01, 2010 9:51 am
I am not sure how this differs from drugs like Campath but it sounded fairly interesting...
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NF kappa B = Nuclear Factor kappa B. It's a transcription factor. When activated in cells, it goes into the nucleus and turns on the transcription of proinflammatory genes.patientx wrote:I don't know, but from my limited understanding it sounds pretty similar to Campath. It looks like the difference might be, whereas Campath, Rituxan, and other MABs, are actually antibodies that bind to T and B cells, this drug causes T cell death by inhibiting NF Kappa B activation (whatever that is). I guess the NF Kappa B is involved in activating inflammatory T-cells, so maybe that's how it leaves "good" T-cells unharmed.
Interesting. Do you have some research that you could point to about these things inhibiting NFkB?NHE wrote:Several supplements inhibit NFkB such as EGCG, curcumin, and R-lipoic acid.
NHE
Jeff's been on EGCG for 3 years. As well as inhibiting NFkB, it is a BBB permeable chelator. Here's a paper on the NFkB affect:patientx wrote:Interesting. Do you have some research that you could point to about these things inhibiting NFkB?NHE wrote:Several supplements inhibit NFkB such as EGCG, curcumin, and R-lipoic acid.
NHE