Gout and MS
Posted: Thu Jul 22, 2010 5:23 am
I have read that people that get gout dont get MS and people that have MS do not get gout... Is this true? have there been any studies to confirm this?
thanks
thanks
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Mult Scler. 2010 Apr;16(4):455-62. Epub 2010 Mar 3.
Boosting endogenous neuroprotection in multiple sclerosis: the ASsociation of Inosine and Interferon beta in relapsing- remitting Multiple Sclerosis (ASIIMS) trial.
Gonsette RE, Sindic C, D'hooghe MB, De Deyn PP, Medaer R, Michotte A, Seeldrayers P, Guillaume D; ASIIMS study group.
Collaborators (47)Gonsette RE, Sindic C, Goffette S, van Pesch V, Duprez T, Demaerel P, D'hooghe MB, Nagels G, Descamps M, Van Remoortel A, Deville MC, van Nunen A, Medaer R, Vanroose E, Bogaerts A, Michotte A, Bissay V, De Boeck M, De Deyn P, Sheorajpanday R, Braxel E, Seeldrayers P, Jacquy J, Piette T, De Cock C, Guillaume D, Reznik R, Metz R, Maertens de Noordhout A, Delvaux V, Dupuis M, Cras P, Willekens B, Timperman H, Decoo D, De Sutter M, Van Zandijcke M, Dehaene I, Verhoeven K, Deryck O, Casselman J, Criel A, Schotte V, Verhaeghe R, Dusautoir C, Hermoye L, Maes F.
National Centre for Multiple Sclerosis, Vanheylenstraat 16, Melsbroek, Belgium. r.gonsette@skynet.be
Abstract
Anti-inflammatory drugs are effective on relapses, but neuroprotective agents to prevent disability are still unavailable. Uric acid has neuroprotective effects in experimental models including encephalomyelitis and appears to be involved in multiple sclerosis. Oral administration of inosine, a precursor of uric acid, increases serum uric acid levels and is well tolerated.
Our objective was to test the possibility that a combination therapy associating an anti-inflammatory drug (interferon beta) and an endogenous neuroprotective molecule (uric acid) would be more effective than interferon beta alone on the accumulation of disability.
Patients with relapsing-remitting multiple sclerosis on interferon beta for at least 6 months were randomized to interferon beta + inosine or interferon beta + placebo for 2 years.
The dose of inosine was adjusted to maintain serum uric acid levels in the range of asymptomatic hyperuricaemia (<or=10 mg/dl).
The primary end points were percentage of patients with progression of disability and time to sustained progression (Kaplan-Meier analysis).
The combination of interferon beta and inosine was safe and well tolerated but did not provide any additional benefit on accumulation of disability compared with interferon beta alone.
We conclude that endogenous neuroprotective mechanisms recently identified in multiple sclerosis are complex and uric acid does not reflect the entire story.
PMID: 20200198 [PubMed - indexed for MEDLINE]
We conclude that endogenous neuroprotective mechanisms recently identified in multiple sclerosis are complex and uric acid does not reflect the entire story.
I have just read your 3 year old posts on Gout and MS. Very interesting.jimmylegs wrote:for THREE YEARS??? that must be horribly painful.
my friend (who does not have MS) got gout and then got rid of it by and large over the last few months.
i just called him to ask about it and he says he has to stay on top of things nutritionally or he starts to get a sense that all is not well.
he first had a bad spell over the winter, took colchicin for a couple weeks, and also cut down on the high protein diet and alcohol.
it went away, then came back, then he took another break from high protein diet and alcohol. this time no colchicin, but added high potency (600mg) potassium pills to the mix (he's not a fan of fresh fruits and veggies AT ALL).
at any rate, he runs a lot so he's pretty aware of how his feet are doing, and he thinks by and large his foot feels best when he stays on top of his potassium intake. just one person's report.
sorry to hear you are one of the ones in that sucky MS + gout boat
Many thanks for your excellent input as usual. This patient has not been diagnosed with MS.jimmylegs wrote:heya, do you mean rrms + gout for 6yrs? at age 24??! not. fun.
to tease out what is going on w your 24 y o friend, I would be looking for food/fluid intake over 3 days, a journal record of all meds, all supplements, all symptoms related and unrelated, all other diagnoses and familial tendencies to illness.
then I would head for the science. bloodwork would be a strong recommendation. we can characterize quite a few levels in the average ms patient, but I doubt we could safely make any assumptions when gout and ms are seen together (if that is indeed the case). a potassium level could be useful, for example, but it is not a test i'm in the habit of suggesting for ms patients. not that it would be hard to find a target level, it's just not really red flagged in the ms research I've seen to date.
here's one bit of reading that could make a useful starting point.
Effect of gradual accumulation of iron, molybdenum and sulfur, slow depletion of zinc and copper, ethanol or fructose ingestion and phlebotomy in gout
http://www.medical-hypotheses.com/artic ... 8/abstract
the author has a similar and very useful article on ms. the nutritional parallels and differences are interesting.
fundamental and likely in large part permanent dietary revisions would likely be key for your friend. if it comes down to choosing a therapeutic course of supplements for a quick initial boost to the biochemistry, 'revital' health looks like a good place to shop - I noticed one across from Victoria stn, but it was closed so I checked out their web site.
hopefully that's a little bit useful!