Determinants of MS in children with acute demyelination
Posted: Wed Apr 20, 2011 11:36 pm
Clinical, environmental, and genetic determinants of MS in children with acute demyelination
Summary
Background
HLA-DRB1*15 genotype, previous infection with Epstein-Barr virus, and vitamin D insufficiency are susceptibility factors for multiple sclerosis, but whether they act synergistically to increase risk is unknown. We aimed to assess the contributions of these risk factors and the effect of established precursors of multiple sclerosis, such as brain lesions on MRI and oligoclonal bands in CSF at the time of incident demyelination, on development of multiple sclerosis in children.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1408
Summary
Background
HLA-DRB1*15 genotype, previous infection with Epstein-Barr virus, and vitamin D insufficiency are susceptibility factors for multiple sclerosis, but whether they act synergistically to increase risk is unknown. We aimed to assess the contributions of these risk factors and the effect of established precursors of multiple sclerosis, such as brain lesions on MRI and oligoclonal bands in CSF at the time of incident demyelination, on development of multiple sclerosis in children.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1408