thought i would check for any updates re the above.
interesting/known to some extent, would be good to learn more along these lines... :
Chu, A., Petocz, P., & Samman, S. (2017).
Plasma/Serum Zinc Status During Aerobic Exercise Recovery: A Systematic Review and Meta-Analysis. Sports Medicine, 47(1), 127-134.
http://link.springer.com/article/10.100 ... 016-0567-0
"Females generally have lower serum zinc levels compared to males [38], which is driven by the different distribution of sex hormones as exemplifed by the interaction between the use of oral contraceptive agents and serum zinc concentrations."
YES a systematic review from 2016
that saved me some time lol
Dante, G., Vaiarelli, A., & Facchinetti, F. (2016). Vitamin and mineral needs during the oral contraceptive therapy: a systematic review. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 3(1), 1-10.
A decrease in the serum concentrations of zinc, selenium, phosphorus and magnesium have been reported in OC users. Such reductions were proportional to the duration of contraceptive use. These reductions may imply a reduction in the probability of having a pregnancy and/or an increase of serious illness for the unborn. In this regard, a supplementation with the above compounds could be useful in OC users, namely for reducing side effects.
next, selected articles through the years. have not checked refs for the above, just using a scant handful of top google scholar results roughly by decade. just wanted an idea of how far back the thinking goes.
Halsted, J. A., Hackley, B. M., & Smith Jr, J. C. (1968).
Plasma-zinc and copper in pregnancy and after oral contraceptives. Lancet, 2, 278-279.
http://www.popline.org/node/469683
"Zinc plasma-concentration
diminished in those taking oral contraceptives from an average normal of 96 µg/dL to 69 µg/dL, and in the pregnant patients to 250 µg/dL."
wording suggests that 250 should be a 25. no full text for me on this one though. can't check. perils of scanning/text recognition/etc
Hess, F. M., King, J. C., & Margen, S. (1977).
Effect of low zinc intake and oral contraceptive agents on nitrogen utilization and clinical findings in young women. J Nutr, 107(12), 2219-2227.
http://bit.ly/2l24VD1
"
Clinical problems developed in all the subjects with serum zinc levels below 50 µg/dL during the study; three of the six with serum zinc levels above 50 µg/dL also complained of clinical symptoms. The results suggest that zinc deficiency through depletion of accessible body zinc stores developed during the 35-day study."
Crews, M. G., Taper, L. J., & Ritchey, S. J. (1980).
Effects of oral contraceptive agents on copper and zinc balance in young women. The American journal of clinical nutrition, 33(9), 1940-1945.
http://bit.ly/2l24VD1
"Plasma concentrations of zinc were not different for the two groups (Table 5), but the plasma copper level was significantly higher
(F < 0.01) in the oral contraceptive users. The copper values are comparable with other reports (1, 3, 5). Plasma zinc concentrations
are in the range of other reports (3, 6, 9). Values in this study are in the upper range of reported concentrations and may reflect the
blood handling procedures used."
so in this one, control group zinc copper ratio was 151/131 = 1.16:1, very close to healthy optimal 1.1:1. OCA group zinc to copper ratio ended up at 130/200 = 0.65:1. that's fine if you're talking copper:zinc ratio. not zinc:copper.
now if someone would just have a look at serum zinc in OCA+, OCA-, MS, and healthy controls, that could be interesting. til then,
Bredholt, M., & Frederiksen, J. L. (2016).
Zinc in multiple sclerosis: a systematic review and meta-analysis. ASN neuro, 8(3), 1759091416651511.
http://journals.sagepub.com/doi/abs/10. ... 1416651511
"The result of the meta-analysis shows a reduction in serum or plasma Zn levels in patients with MS with a 95% CI of [−3.66, −0.93] and a p value of .001 for the difference in Zn concentration in μM."
and now, for something where you can see the actual levels...
Ghazavi, A., Kianbakht, S., Ghasami, K., & Mosayebi, G. (2012).
High copper and low zinc serum levels in Iranian patients with multiple sclerosis: a case control study. Clin Lab, 58(1-2), 161-164.
http://bit.ly/2lwAcyR
Table 1
..........................MS...:...................SPMS...:.................RRMS...:..............Controls
Zn level (µg/dL)...40.17 ±31.89a........23.12 ±10.59c.......42.06 ±32.94.......127.77 ±42.2
Cu level (µg/dL)..114.05 ±42b.........126.14 ±44.20.......111.22 ±39.45.........91.3 ±37
note the completely inverted copper zinc ratios, bad for RRMS and TERRIBLE for SPMS
zn:cu
Controls.....127.8/ 91.3 =
1.4 (pretty high to my eye, unusual)
RRMS..........42.1/ 111.2 =
0.38 (awfully low, needs to be more like 1.1)
MS..............40.2/ 114.1 =
0.35 (splitting the difference between RRMS and SPMS)
SPMS..........23.1/ 126.1 =
0.18 (makes sense that this one is worst of all)
from other sources,
optimal = 1.1
yikes, this crew *wishes* they were playing with the +/- 50 µg/dL groups above :S
overall, in this last study, looks like MS patients of all stripes tended to have even lower zinc levels than women on OCA meds in the studies above.
remember that so-called new 'inhalational' alzheimer's study? because i do... crap ratios all across the board. except i used cu/zn in that review so aiming for 0.7-1.0 as the sweet spot:
http://www.thisisms.com/forum/natural-a ... ml#p245062