Posted: Fri Feb 03, 2006 5:32 pm
well I ccame across this and wanted to share it. The idea that a high insulin level can be a problem for MSer that Lnda Carol put forth here and that she is so convinced is at issue ties in to DHEA :
Title: Mechanism of Mast Cell Activation
Author: Peters, SP
Year: 1995
Series Editor: Holgate, Busse and
Series Title: Blackwell Scientific Publications
Volume: Asthma and Rhinitis
Number of Pages: 221-230
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Title: Dehydroepiandrosterone (Dhea)--the "Mother Steroid". I. Immunologic Action
Author: Regelson, W.; Loria, R.; Kalimi, M.; (Date: May 31, 1994)
Journal: Ann N Y Acad Sci; V. 719; Pages: 553-63
Notes: Journal Article
Review
Review, Tutorial
Author Address: Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
--------------------------------------------------------------------------------
Title: Case Report: Amelioration of Insulin Resistance in Diabetes with Dehydroepiandrosterone
Author: Buffington, C. K.; Pourmotabbed, G.; Kitabchi, A. E.; (Date: Nov, 1993)
Journal: Am J Med Sci; V. 306; Issue: 5; Pages: 320-4
Abstract: In hyperandrogenic females, the ratio of dehydroepiandrosterone (DHEA) to testosterone may be an important determinant of insulin sensitivity. This study involved changes in insulin sensitivity and glucose metabolism with therapeutic manipulation of DHEA (S)/testosterone in a female patient with non-insulin-dependent diabetes and hyperandrogenism. Therapeutic intervention included 1-month treatment with 0.25 mg dexamethasone at bedtime and 1-month dexamethasone + DHEA. Insulin sensitivity and glucose tolerance were assessed before and after each treatment regimen by examining: 1) fasting and oral glucose tolerance test glucose and insulin levels, 2) hypoglycemic response to intravenous insulin, and 3) erythrocyte insulin receptor binding. With dexamethasone alone, DHEAS, testosterone, and their ratio were reduced with a concomitant increase (30%) in oral glucose tolerance test insulin levels and a decrease (33%) in erythrocyte insulin binding. With DHEA + dexamethasone, the ratio of DHEAS/testosterone increased 16-fold along with a marked improvement in insulin sensitivity, as determined by a more than 30% reduction in fasting and oral glucose tolerance test insulin levels, a threefold stimulation of the rate of glucose disappearance with intravenous insulin, and a 30% increase in insulin binding. DHEA improved insulin sensitivity and reduced fasting and oral glucose tolerance test glucose levels and ameliorated the diabetic state. The ratio of DHEAS/testosterone is an important regulator of insulin sensitivity and glucose tolerance and that DHEA therapy may be beneficial in the treatment of certain forms of insulin resistance.
Notes: Journal Article
Author Address: Department of Medicine, University of Tennessee, Memphis.
I hope Sharon weighs in on this. I remember that DHEA is low in MS and adding apparently can be helpful, but don't have these studies at hand as it's not my area of interest. But perhaps the way to reduce insulin sensitivity is to think about that kind of approach. As usual talk that over with your doc (naturopath in this case... are you in the US?)
marie
Title: Mechanism of Mast Cell Activation
Author: Peters, SP
Year: 1995
Series Editor: Holgate, Busse and
Series Title: Blackwell Scientific Publications
Volume: Asthma and Rhinitis
Number of Pages: 221-230
--------------------------------------------------------------------------------
Title: Dehydroepiandrosterone (Dhea)--the "Mother Steroid". I. Immunologic Action
Author: Regelson, W.; Loria, R.; Kalimi, M.; (Date: May 31, 1994)
Journal: Ann N Y Acad Sci; V. 719; Pages: 553-63
Notes: Journal Article
Review
Review, Tutorial
Author Address: Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
--------------------------------------------------------------------------------
Title: Case Report: Amelioration of Insulin Resistance in Diabetes with Dehydroepiandrosterone
Author: Buffington, C. K.; Pourmotabbed, G.; Kitabchi, A. E.; (Date: Nov, 1993)
Journal: Am J Med Sci; V. 306; Issue: 5; Pages: 320-4
Abstract: In hyperandrogenic females, the ratio of dehydroepiandrosterone (DHEA) to testosterone may be an important determinant of insulin sensitivity. This study involved changes in insulin sensitivity and glucose metabolism with therapeutic manipulation of DHEA (S)/testosterone in a female patient with non-insulin-dependent diabetes and hyperandrogenism. Therapeutic intervention included 1-month treatment with 0.25 mg dexamethasone at bedtime and 1-month dexamethasone + DHEA. Insulin sensitivity and glucose tolerance were assessed before and after each treatment regimen by examining: 1) fasting and oral glucose tolerance test glucose and insulin levels, 2) hypoglycemic response to intravenous insulin, and 3) erythrocyte insulin receptor binding. With dexamethasone alone, DHEAS, testosterone, and their ratio were reduced with a concomitant increase (30%) in oral glucose tolerance test insulin levels and a decrease (33%) in erythrocyte insulin binding. With DHEA + dexamethasone, the ratio of DHEAS/testosterone increased 16-fold along with a marked improvement in insulin sensitivity, as determined by a more than 30% reduction in fasting and oral glucose tolerance test insulin levels, a threefold stimulation of the rate of glucose disappearance with intravenous insulin, and a 30% increase in insulin binding. DHEA improved insulin sensitivity and reduced fasting and oral glucose tolerance test glucose levels and ameliorated the diabetic state. The ratio of DHEAS/testosterone is an important regulator of insulin sensitivity and glucose tolerance and that DHEA therapy may be beneficial in the treatment of certain forms of insulin resistance.
Notes: Journal Article
Author Address: Department of Medicine, University of Tennessee, Memphis.
I hope Sharon weighs in on this. I remember that DHEA is low in MS and adding apparently can be helpful, but don't have these studies at hand as it's not my area of interest. But perhaps the way to reduce insulin sensitivity is to think about that kind of approach. As usual talk that over with your doc (naturopath in this case... are you in the US?)
marie