This Is MS Multiple Sclerosis Knowledge & Support Community

jimmylegs wrote:prions and protein misfolding seemed to enjoy a few mentions here a few years ago, off my radar entirely until this year. thoughts on that angle?

HarryZ wrote:Interesting comment about other autoimmune diseases. My wife, who had MS for 36 years, rarely had a cold or any kind of viral problem after her first attack. I can remember her neuro telling her years ago that they thought MS patients had an overactive immune system and, as a result, didn't come down with other viral diseases nearly as often as other people. Yet, as a teenager, she had the measles 3 times! Go figure.

cervocuit wrote:It’s an interesting theory, but does dr Stys explains in his paper what we can see on MRI ?
Does he think that the neurodegeneration is disseminated in time and space (not the case in Alzheimer) ? Otherwise, the neurodegeneration is global and for those who have a reactiv immune systetm (the youngs), it clean up only selected debris between whiles for some reason ?

There is also evidences that people with MS has more chance to develop other autoimmune deseases. It’s hard to believe that a slow neurodegeneration would create acute inflammation in bowel or joints. The only one person with MS that I know personally had hashimoto’s thyroidis 5 years before the first symptom of MS.

The inside-out model of MS (FIG. 1) proposes that in MS, there is a primary ‘cytodegeneration’ that might initially be focused on the oligodendrocytes and myelin, presumably beginning years before any overt clinical symptoms occur (BOX 1). What sets MS
apart from other monotonically progressive neurodegenerative disorders is the host’s predilection to react to the highly autoantigenic components (for example, citrullinated myelin basic protein (MBP)35, myelin lipids36 and externalized phosphatidylserine from ‘apoptotic myelin membranes’ (REF.12)) that are released as a consequence of the cytodegeneration.
Thus, this model proposes that MS results from a convolution between progressive cytodegeneration and a variably
primed immune system.

One thing I have noticed since I started diet, is an unexpected and total disparition of allergies, which are not other things than an immune system overreaction. That’s why I found this old paper of Dr.Jonez very interesting.
http://www.ncbi.nlm.nih.gov/pmc/article ... 14/?page=1

“I guess we have no choice, do we? I mean, there
is so much push and pressure,” Dr. Peter Stys, a
professor of clinical neuroscience and an MS
researcher at the University of Calgary says of the
money being poured into CCSVI research at record
speed. Stys does not deal directly with MS patients
but he does research the disease. “I think if this
issue went through (the) normal, regular, sober,
peer-review process, it wouldn’t go nearly as
far . . . (as) it has at the moment, because the
science is just not there.”

cheeleader wrote:And yes, this can be measured by MRI. There is measurable atrophy in the thalamus, brain stem, cortex and other deep gray matter areas, but Stys does not go into MRI---that's not his area of expertise...

I guess Stys is going for the money now.

CVfactor wrote:If the beak fits........

Dr. Peter Stys, a professor of clinical neuroscience and an MS researcher at the University of Calgary, said the findings show CCSVI may be a response from the way veins have drained over the years from a brain inflamed by MS and other neuroinflammatory diseases.
“Importantly, CCSVI is no more the cause of MS than a swollen ankle is the cause of the underlying
fractured bone,” Stys said. “Therefore, stenting veins in CCSVI will not cure MS any more than icing the ankle will somehow fix the fractured bone.”

CVfactor wrote:Also, if MS was homogenous it would not only effect the eight functional systems as measured in the EDSS scale.

The eight Functional Systems (FS) and their
abbreviations are as follows:
Pyramidal (motor function) (P)
Cerebellar (C11)
Brainstem (BS)
Sensory (S)
Bowel and Bladder (BB)
Visual (V)
Cerebral or Mental (Cb)
Other (O)

I never heard of that before, but from a quick research, they are suspected in neurodegeneratives disease but not MS?

Nothing about prions or proteins in this paper, JL...