I am not convinved by this study.
I think that MS is a complex two stage disease with different underlying mechanisms, see e.g.
http://www.thisisms.com/forum/general-d ... 15188.html
Making this differentiation is essential when studying possible treatment options or drugs.
If the study design is wrong or based on the wrong presumptions, you will never find the right answer...
From the press release: "There are many genes associated with MS, but we know little about the role they play or the influence they have on the condition."
I think there are many genes, molecular and cellular pathways and interactions with the immune system that have not been understood so far.
And I am sure that is true for many many diseases, not just for MS....
It is a bit like the search for the Higgs boson and the uncertainties surrounding this research see e.g.
...
This gene study reported here is a continuation of the old line of thinking, about fancy genetic deficiencies and the like.
But that model is broken; I think the goal is unattainable..
I think the answer is much simpler:
- many years of ccsvi causes weakening of endothelium and lymphatic system; early treatment by angioplasty could be useful as a pre-emptive measure;
- the first peak in the MS onset graph is caused by Cpn or EBV blocking receptors; may be treated by a good dose of anti-biotics;
- in the second peak, it is a deficiency in the glucose metabolism that causes the immune system reaction. In stead of studying all these very advanced drugs, there may be much simpler and more effective solutions such as Metformin, that -incidently - also work via the gut flora. Or a gut flora transplant. Or a diet. see e.g.
http://www.thisisms.com/forum/general-d ... 8-330.html
There are some postings on this thread under this link on how the fancy genetic research is now quickly being replaced by research into the health and workings of nuclear receptors..
Has Metformin ever been studied for MS? I know for Alzheimer, the drug is under study in Berlin and apparently gives promising results. Why not study it for MS? The prevalence of diabetes in MS would at the very least suggest to be a good reason to have a closer look...