Effects of a Ketogenic Diet in a Murine Model of MS
Posted: Mon Jul 16, 2012 6:50 pm
I was just scouting around looking at Ketogenic Diet (KD) and diseases,
KD was the original treatment for epilepsy until drugs were available and has come back into use for drug resistant epilepsy with great success, studies have shown it can benefit a variety of diseases including Diabetes, Alzheimers, Metabolic Syndrome & NAFL and there is some research starting to look at Parkinsons.
I just stumbled across this link to a study on KD effect on MS, published may 2012, it was done on mice of course, but there may be something in it.
http://www.plosone.org/article/info%3Ad ... ne.0035476
Inflammation-Mediated Memory Dysfunction and Effects of a Ketogenic Diet in a Murine Model of Multiple Sclerosis
Received: September 15, 2011; Accepted: March 18, 2012; Published: May 2, 2012
In summary, we have shown that memory deficits in EAE mice are correlated with brain inflammation as evidenced by the enhanced expression of inflammatory cytokines and chemokines. And importantly, the KD significantly attenuated brain inflammation and reversed both memory dysfunction and motor impairment in EAE mice. There is mounting evidence that metabolic substrates (and certain hormones) can reduce inflammatory responses, and as a consequence provide both structural and functional neuroprotective effects. Since the KD is currently available in many clinical centers throughout the world, patients with MS may readily benefit from this non-pharmacological treatment option. In light of the present study and supportive evidence from the literature noted above, prospective, controlled clinical trials assessing the therapeutic effects of the KD now appear warranted.
KD was the original treatment for epilepsy until drugs were available and has come back into use for drug resistant epilepsy with great success, studies have shown it can benefit a variety of diseases including Diabetes, Alzheimers, Metabolic Syndrome & NAFL and there is some research starting to look at Parkinsons.
I just stumbled across this link to a study on KD effect on MS, published may 2012, it was done on mice of course, but there may be something in it.
http://www.plosone.org/article/info%3Ad ... ne.0035476
Inflammation-Mediated Memory Dysfunction and Effects of a Ketogenic Diet in a Murine Model of Multiple Sclerosis
Received: September 15, 2011; Accepted: March 18, 2012; Published: May 2, 2012
In summary, we have shown that memory deficits in EAE mice are correlated with brain inflammation as evidenced by the enhanced expression of inflammatory cytokines and chemokines. And importantly, the KD significantly attenuated brain inflammation and reversed both memory dysfunction and motor impairment in EAE mice. There is mounting evidence that metabolic substrates (and certain hormones) can reduce inflammatory responses, and as a consequence provide both structural and functional neuroprotective effects. Since the KD is currently available in many clinical centers throughout the world, patients with MS may readily benefit from this non-pharmacological treatment option. In light of the present study and supportive evidence from the literature noted above, prospective, controlled clinical trials assessing the therapeutic effects of the KD now appear warranted.