Aldosterone and MS
Posted: Thu Dec 13, 2012 8:14 am
I am moving my posts on this topic from the CCSVI forum as aldosterone doesn’t seem to be implicated in the cause of CCSVI due to congenital valve abnormalities.
The original thread can be found here…
http://www.thisisms.com/forum/chronic-c ... 21244.html
Here are the potentially significant links from that thread. Will add anything else I find to this thread.
Immune Response-BBB and Aldosterone
Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity
http://www.jimmunol.org/content/184/1/191.short
CD8 T Cell-Initiated Blood–Brain Barrier Disruption Is Independent of Neutrophil Support
http://www.jimmunol.org/content/189/4/1937.abstract
Aldosterone increases VEGF-A production in human neutrophils through PI3K, ERK1/2 and p38 pathways
http://www.sciencedirect.com/science/ar ... 8911001996
CD8 T Cell-Initiated Vascular Endothelial Growth Factor Expression Promotes Central Nervous System Vascular Permeability under Neuroinflammatory Conditions
http://www.jimmunol.org/content/184/2/1031.abstract
VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
http://www.pnas.org/content/106/6/1977.abstract
Insulin Issues and Aldosterone
Insulin Resistance and Hyperinsulinemia Are Related to Plasma Aldosterone Levels in Hypertensive Patients
http://care.diabetesjournals.org/conten ... 2349.short
Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor
http://atvb.ahajournals.org/content/32/2/257.abstract
Vascular-BBB Issues and Aldosterone
“Aldosterone-induced profibrotic effects lead to reduced arterial compliance and impaired baroreflex activity and, consequently, to impaired autonomic control of cardiac and vascular function”
http://cardiovascres.oxfordjournals.org ... 4/663.full
Aldosterone Promotes Endothelial Dysfunction Via Prostacyclin Independent of Hypertension
http://hyper.ahajournals.org/content/46/1/29.full
Hypertension-induced venous valve remodeling
http://www.sciencedirect.com/science/ar ... 1404003830
Idiopathic Intracranial Hypertension Associated with Either Primary Or Secondary Aldosteronism
http://journals.lww.com/amjmedsci/Abstr ... 99172.aspx
Aldosterone blunts the baroreflex response in man
http://www.clinsciusa.org/cs/095/0687/0950687.pdf
Uric Acid and Aldosterone
Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction.
http://www.ncbi.nlm.nih.gov/pubmed/11985629
Uric acid in multiple sclerosis
http://www.ingentaconnect.com/content/m ... 3/art00015
“In animal models, aldosterone infusion causes endothelial dysfunction via the generation of ROS (reactive oxygen species) [22–24]. Aldosterone increases expression of NADPH oxidase subunits p22pbox and gp91phox through an MR-dependent mechanism, whereas aldosterone stimulates expression of p47phox mRNA through both AT1 receptor and MR-dependent mechanisms (Figure 2) [25,26]. The resultant generation of ROS leads to the formation of peroxynitrite”
http://submit.clinsci.org/cs/113/0267/cs1130267.htm
Uric Acid: Eplerenone (aldosterone blocker) produced increases in uric
acid to greater than 9 mg/dL in approximately 0.3%
http://www.hsc.wvu.edu/Charleston/sop/C ... /jun04.pdf
Nutrition and Aldosterone
Renin-angiotensin-aldosterone System: Target of Vitamin D Protection and Therapy
http://www.ibridgenetwork.org/uctech/uchi-1709
Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans.
http://www.ncbi.nlm.nih.gov/pubmed/21718915
Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone.
http://www.ncbi.nlm.nih.gov/pubmed/17616752
Magnesium supplementation can lower aldosterone levels. Mg deficiency elevates aldosterone production. Vitamin D can lower aldosterone levels. Like MS, hypertension (aldosterone-connected) is much less prevalent in the tropics.
http://www.immortalhair.org/physiology.htm
MS onset, progression and Aldosterone (aldosterone goes up in tandem with cortisol)
Studies on MS Onset
http://content.karger.com/ProdukteDB/pr ... 323953.pdf
Allostatic load model
http://www.fatiguesymposium.ca/pdf/Just ... static.pdf
Aldosterone: A forgotten mediator of the relationship between psychological stress and heart disease
http://www.sciencedirect.com/science/ar ... 340900102X
Dysregulation of the hypothalamo-pituitary-adrenal axis is related to the clinical course of MS
http://www.neurology.org/content/53/4/772.short
Onset of multiple sclerosis associated with anti-TNF therapy
http://www.neurology.org/content/57/10/1885.short
Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
http://www.neurology.org/content/47/6/1531.short
Tumor Necrosis Factor and Interleukin-1 Are Potent Inhibitors of Angiotensin-II-Induced Aldosterone Synthesis*
http://endo.endojournals.org/content/125/6/3084.short
Helminths, LDN and Aldosterone
Basal and ACTH-Stimulated Plasma Aldosterone Concentrations are Normal or Increased in Dogs With Trichuriasis-Associated Pseudohypoadrenocorticism
http://www.ncbi.nlm.nih.gov/pubmed/7983625
Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
http://endo.endojournals.org/content/151/8/3836.short
Influence of Antiopioids on Luteinizing Hormone Pulsatility in Aging Men
http://jcem.endojournals.org/content/68/1/68.short
How complicated can this get?! and Aldosterone
The role of natriuretic peptides in cardioprotection
http://cardiovascres.oxfordjournals.org ... 2/318.full
Suppression of Luteinizing Hormone Secretion by Atrial and Brain Natriuretic Peptides in Ovariectomized Rats*
http://endo.endojournals.org/content/129/2/801.short
The original thread can be found here…
http://www.thisisms.com/forum/chronic-c ... 21244.html
Here are the potentially significant links from that thread. Will add anything else I find to this thread.
Immune Response-BBB and Aldosterone
Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity
http://www.jimmunol.org/content/184/1/191.short
CD8 T Cell-Initiated Blood–Brain Barrier Disruption Is Independent of Neutrophil Support
http://www.jimmunol.org/content/189/4/1937.abstract
Aldosterone increases VEGF-A production in human neutrophils through PI3K, ERK1/2 and p38 pathways
http://www.sciencedirect.com/science/ar ... 8911001996
CD8 T Cell-Initiated Vascular Endothelial Growth Factor Expression Promotes Central Nervous System Vascular Permeability under Neuroinflammatory Conditions
http://www.jimmunol.org/content/184/2/1031.abstract
VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
http://www.pnas.org/content/106/6/1977.abstract
Insulin Issues and Aldosterone
Insulin Resistance and Hyperinsulinemia Are Related to Plasma Aldosterone Levels in Hypertensive Patients
http://care.diabetesjournals.org/conten ... 2349.short
Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor
http://atvb.ahajournals.org/content/32/2/257.abstract
Vascular-BBB Issues and Aldosterone
“Aldosterone-induced profibrotic effects lead to reduced arterial compliance and impaired baroreflex activity and, consequently, to impaired autonomic control of cardiac and vascular function”
http://cardiovascres.oxfordjournals.org ... 4/663.full
Aldosterone Promotes Endothelial Dysfunction Via Prostacyclin Independent of Hypertension
http://hyper.ahajournals.org/content/46/1/29.full
Hypertension-induced venous valve remodeling
http://www.sciencedirect.com/science/ar ... 1404003830
Idiopathic Intracranial Hypertension Associated with Either Primary Or Secondary Aldosteronism
http://journals.lww.com/amjmedsci/Abstr ... 99172.aspx
Aldosterone blunts the baroreflex response in man
http://www.clinsciusa.org/cs/095/0687/0950687.pdf
Uric Acid and Aldosterone
Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction.
http://www.ncbi.nlm.nih.gov/pubmed/11985629
Uric acid in multiple sclerosis
http://www.ingentaconnect.com/content/m ... 3/art00015
“In animal models, aldosterone infusion causes endothelial dysfunction via the generation of ROS (reactive oxygen species) [22–24]. Aldosterone increases expression of NADPH oxidase subunits p22pbox and gp91phox through an MR-dependent mechanism, whereas aldosterone stimulates expression of p47phox mRNA through both AT1 receptor and MR-dependent mechanisms (Figure 2) [25,26]. The resultant generation of ROS leads to the formation of peroxynitrite”
http://submit.clinsci.org/cs/113/0267/cs1130267.htm
Uric Acid: Eplerenone (aldosterone blocker) produced increases in uric
acid to greater than 9 mg/dL in approximately 0.3%
http://www.hsc.wvu.edu/Charleston/sop/C ... /jun04.pdf
Nutrition and Aldosterone
Renin-angiotensin-aldosterone System: Target of Vitamin D Protection and Therapy
http://www.ibridgenetwork.org/uctech/uchi-1709
Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans.
http://www.ncbi.nlm.nih.gov/pubmed/21718915
Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone.
http://www.ncbi.nlm.nih.gov/pubmed/17616752
Magnesium supplementation can lower aldosterone levels. Mg deficiency elevates aldosterone production. Vitamin D can lower aldosterone levels. Like MS, hypertension (aldosterone-connected) is much less prevalent in the tropics.
http://www.immortalhair.org/physiology.htm
MS onset, progression and Aldosterone (aldosterone goes up in tandem with cortisol)
Studies on MS Onset
http://content.karger.com/ProdukteDB/pr ... 323953.pdf
Allostatic load model
http://www.fatiguesymposium.ca/pdf/Just ... static.pdf
Aldosterone: A forgotten mediator of the relationship between psychological stress and heart disease
http://www.sciencedirect.com/science/ar ... 340900102X
Dysregulation of the hypothalamo-pituitary-adrenal axis is related to the clinical course of MS
http://www.neurology.org/content/53/4/772.short
Onset of multiple sclerosis associated with anti-TNF therapy
http://www.neurology.org/content/57/10/1885.short
Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2
http://www.neurology.org/content/47/6/1531.short
Tumor Necrosis Factor and Interleukin-1 Are Potent Inhibitors of Angiotensin-II-Induced Aldosterone Synthesis*
http://endo.endojournals.org/content/125/6/3084.short
Helminths, LDN and Aldosterone
Basal and ACTH-Stimulated Plasma Aldosterone Concentrations are Normal or Increased in Dogs With Trichuriasis-Associated Pseudohypoadrenocorticism
http://www.ncbi.nlm.nih.gov/pubmed/7983625
Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
http://endo.endojournals.org/content/151/8/3836.short
Influence of Antiopioids on Luteinizing Hormone Pulsatility in Aging Men
http://jcem.endojournals.org/content/68/1/68.short
How complicated can this get?! and Aldosterone
The role of natriuretic peptides in cardioprotection
http://cardiovascres.oxfordjournals.org ... 2/318.full
Suppression of Luteinizing Hormone Secretion by Atrial and Brain Natriuretic Peptides in Ovariectomized Rats*
http://endo.endojournals.org/content/129/2/801.short