Re: Aldosterone and MS
Posted: Sat Jan 05, 2013 2:44 pm
Another genotype associated with hyper-reactive hpa-axis.
http://onlinelibrary.wiley.com/doi/10.1 ... ated=false
http://onlinelibrary.wiley.com/doi/10.1 ... ated=false
Conclusions The C4B*Q0 genotype may be associated with hyperreactivity of the HPA axis (manifested as an increased responsiveness to ACTH-stimulation), probably through enhanced function of steroid 21-hydroxylase. Since hyperreactivity of the HPA axis is known to be associated with an increased risk of cardiovascular disease, our present findings may explain the increased cardiovascular morbidity and mortality of C4B*Q0 carriers.