This Is MS Multiple Sclerosis Knowledge & Support Community

http://www.medicalnewstoday.com/releases/255694.php

http://en.wikipedia.org/wiki/Klotho_(biology)

http://www.jneurosci.org/content/33/5/1927.abstract

It is mice again, but who knows.

http://lewrockwell.com/sardi/sardi245.html

If we follow the information, written above we can see that inflammation causes less growth factor that is needed for Klotho synthesis.

I believe that metformin has helped somebody in this forum. This pill increases the groth factor.

As seen below, klotho is linked to vitamin d, calcium, N, K and insulin. All of them were linked to MS by a lot of forum members.

My main theory is that the kidneys are involved with this degenerative disease. Maybe i am wrong.

Dig people, dig through the information available on internet.

Good find! The really neat thing about this is we might be able to see what happens in MS with increased klotho when the Lisinopril study results are published. ACE inhibitors reduce Ang II. A reduction in Ang II is associated with an increase in klotho. So, good results from the study might just be partially attributable to upregulation of klotho. I do worry that the Lisinopril study results will be tainted by aldosterone breakthrough.

It seems like "they" are moving really fast with new discoveries about the impact of hormones outside of their traditionally known domains. Maybe it won't be too long before we have some answers.

Edited to rephrase. I don't recommend posting while chatting on the phone.

good find!

I take Metformin

see the last 4-5 pages of http://www.thisisms.com/forum/general-d ... 15188.html

Leonard wrote:good find!

I take Metformin

see the last 4-5 pages of http://www.thisisms.com/forum/general-d ... 15188.html

Hi Leonard,
I was poking around Metformin trying to decide if it would be a better option than Clonidine. I stumbled across a page that warned of the dangers of B12 deficiency with metformin. http://www.metforminsideeffects.co/ I just thought I'd share in case that is what is holding back regaining sensation (I think I read that in the other thread). After reading a bit of your thread, I'm pretty sure you already know about that risk. Clonidine's not perfect either...can cause CQ10 deficiency.

Any recent improvements from Metformin?