This Is MS Multiple Sclerosis Knowledge & Support Community

Anyone research or try Inosine? I came across in interesting article and Inosine is currently is phase 2 trials. I am going to add it to my regime, just wanted some other input.

I use it. I like the research I've seen and the only risk seems to be gout.

I started a different thread a few months back on the Regimines forum.

If you search, there is interesting material going back a few years.

Here is one... http://www.thisisms.com/forum/regimens- ... it=inosine

I take it in overdose and also molybdenum on an irregular schedule

I tried it for a couple years but found no benefit.

Conclusions. Our data suggest that raising serum UA levels by the oral administration of inosine treatment may benefit patients with MS. Improvements in EDSS and a reduction in lesion activity were noted. Studies in a larger cohort are indicated and will help to elucidate the mechanistic effects of the treatment.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189001/

http://www.ncbi.nlm.nih.gov/pmc/article ... figure/f1/

Re: gout - I read on this forum that gout and MS were mutually exclusive.

PN

Sorry PN but I have both confirmed! MS and Gout !

Thanks lbug. You can never trust what you read here !

did you try finding the research? "statistical evaluation of more than 20 million patient records for the incidence of MS and gout (hyperuricemic) revealed that the two diseases are almost mutually exclusive, raising the possibility that hyperuricemia may protect against MS." 20 mil? that's some serious 'n'. you can take that sucker to the bank. nevertheless, almost is almost. i have an ms dx and managed to give myself gout briefly but it was years *after* I fixed my ms-characteristic low uric acid level (with zinc not inosine).

was your gout a self diagnosis or doctor confirmed?

self. gout doesn't take a genius to dx. i eat lots of some known gout triggers, my foot goes to hell. I stop eating them, foot feels better. rinse and repeat. ok lesson learned.

"It is well recognised that in certain gouty people small quantities of such things as cider, asparagus, rhubarb and strawberries can produce typical attacks of gout" (1939)

a diagnostic checklist

Confirming the diagnosis
http://www.nhs.uk/Conditions/Gout/Pages/Diagnosis.aspx
"As checking the joints for crystals is not always practical in general practice, a checklist is often used. This is based on the known pattern of symptoms associated with the condition.
The checklist used is as follows:
•You have had more than one attack with symptoms of pain, swelling and inflammation.
•You have experienced high levels of inflammation within just one day of the onset of symptoms.
•Symptoms only affect one joint at a time.
•The joint in your big toe or other foot joints have been affected.
•Results of the serum acid test show raised levels of uric acid in your blood.
•Physical examination or X-rays have detected swelling within a joint.
•There is no evidence that your joint has been infected by bacteria.
You will usually be diagnosed with gout if at least six of the statements above apply to you."

Case report 599 (1990)
http://www.ccjm.org/content/75/Suppl_5/S9.full.pdf
"The term oxalate gout has been suggested for the occurrence of joint involvement and symptoms in secondary oxalosis [8], acknowledging its first use by Loeper in 1932."

Articular Oxalate Crystals and the Taxonomy of Gout (1988)
http://jama.jamanetwork.com/article.asp ... eid=373733
"Rosenthal et al1 report the case of an anephric, dialyzed patient experiencing acute arthritis associated with calcium oxalate crystals. Together with reports from Hoffman et al,2 Schumacher et al,3 and Reginato et al,4 this observation establishes an unequivocal place for oxalate among the solutes that abnormally crystallize in and around human joints."

The topic of this thread is related to the reason (uric acid) why MS and gout are nearly mutually exclusive, and also why the exception to the rule is posting in this thread. The research on inosine for abatement of MS symptoms indicates that kidney stones and gout are potential risks of raising serum uric acid levels, which is what inosine does.

The protocol for people taking isosine in phase II trials includes at least 8 glasses of water a day. That has me taking a lot of trips to the bathroom. ) :

Regarding the person who saw no effect from inosine, have you had your serum zinc levels measured? I am NOT a fan of blindly supplementing with zinc - it can exacerbate MS. However if you are zinc deficient the body won't be able to convert the inosine to uric acid (so it will be ineffective).

your body can't make its own inosine without zinc either. if you optimize a low-normal or deficient zinc level, you may not even require supplemental inosine.

"Inosine 5'-monophosphate first must be converted to inosine by the action of the enzyme ecto-5'-nucleotidase before it can be transported into the cell"
www.ncbi.nlm.nih.gov/pubmed/2985697

Ecto 5' nucleotidase (5'NT) as a sensitive indicator of human zinc deficiency.
http://www.ncbi.nlm.nih.gov/pubmed/1940572
"Our studies show that 5'NT activity may be a sensitive and useful indicator of mild deficiency of zinc in human subjects"

I was under the impression that if you have MS, you cannot have Gout and vice versa. That would be all the "exclusive" talk?