Serum carnosinase activities in CNS disororders
Posted: Sun Jun 09, 2013 6:43 pm
I do not claim to know the full extent of where this is heading, but thought someone else may find it of interest if only as a (possible) extra fact to know. I searched the site, and found no other references to the study. Basically, carnosinase is pretty low in MS compared to normals and even other CNS diseases.
Normals - 161
Epilepsy - 148
MND - 155
Parkinsons - 109
Multiple Sclerosis - 82.5
Cerebrovascular accident - 74.6 (interesting, while still not wishing to cross-post...)
Serum carnosinase activities in central nervous system disorders
Normals - 161
Epilepsy - 148
MND - 155
Parkinsons - 109
Multiple Sclerosis - 82.5
Cerebrovascular accident - 74.6 (interesting, while still not wishing to cross-post...)
Serum carnosinase activities in central nervous system disorders
http://www.ncbi.nlm.nih.gov/pubmed/8033354Serum carnosinase activity was assayed in five groups of patients with neurological disorders. Enzyme activities in patients with idiopathic epilepsy (mean ± S.E.M., 148 ± 11 nmol/ml per min) and motor neurone disease (155 ± 15 nmol/ml per min) were similar to the control group (161 ± 7 nmol/ml per min). Reduced serum carnosinase activity was observed in patients with Parkinson's disease (109 ± 11 nmol/ml per min, P < 0.005), multiple sclerosis (82.5 ± 10.0 nmol/ml per min, P < 0.005) and patients following a cerebrovascular accident (74.6 ± 5.4 nmol/ml per min, P < 0.001) compared with the control group. Carnosinase activity, 5–10% of that found in serum, was detected in CSF samples. The cause of reduced serum carnosinase activities in central nervous system disorders is unclear, although anoxic damage to carnosinase-producing cells or disruption of the blood-brain barrier may be responsible.