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jimmylegs, I reread your post and it seems we may not be in disagreement at all. "sudden high dosing."

One thing that comes to mind regarding "sudden high dosing" is Mg IV's and Mg shots: are these not useful? I guess gradual increases are not the only way with Mg. I do like the idea though, but I want the Mg now!

jimmylegs wrote:speak of the devil, was just going over this elsewhere and, indeed! shock to the system. the body is not designed for sudden high dosing in concentrations far higher than any food. personally, i tend to spread out doses and coincidentally it approximates reasonable serving sizes (eg, i'll take 100mg at a time, and a cup of boiled spinach delivers about 150mg)

Could Mg that does not have to go through the GI tract (transdermal Mg) obey totally different rules?

they're different mechanisms but it is still possible to overdo both shots and transdermal.

check out early research, they killed dogs trying to find out if magnesium acted as a laxative when injected

PHYSIOLOGICAL AND PHARMACOLOGICAL STUDIES OF MAGNESIUM SALTS.—II. THE TOXICITY OF INTRAVENOUS INJECTIONS; IN PARTICULAR THE EFFECTS UPON THE CENTRES OF THE MEDULLA OBLONGATA (1906)
http://ajplegacy.physiology.org/content ... 87.extract

they use magnesium injections for all kinds of things safely but I don't know what level of injected mag is considered safe, or how the change in serum level upon injection would compare to oral dose response.

whatever the route into your system, it's still only in your blood. once your background levels are depleted, depending how far it's gone it could still take loads of time to restock tissue stores.

"they're different mechanisms but it is still possible to overdo both shots and transdermal."

Agreed!