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I think that this study http://www.biomedcentral.com/1471-2377/13/111/ links all the parts of the puzzle; genes, prehistoric viruses like EBV and the immune system. its hard to refute 350 MS patients and 500 control patients. If the herv-fc1 for RRMS and SPMS and herv-fc16 for PPMS retrovirus is discovered in other studies and the HIV drug trial is effective you have the cause and effect of the disease plus a bonafide treatment.

milesap: Very interesting. The part that caught my eye?: "However, we sorely miss the identification of normo-physiological mechanisms other than actual replication that can enhance endogenous virus expression to an extent leading to activation of the immune system. Late infection with Epstein Barr Virus (EBV) is associated with MS, and in vitro EBV infection of blood leucocytes and astrocytes leads to activation of HERVs [41]. Maybe, late EBV infection in vivo triggers large scale HERV activation."