Desipramine & MS
Posted: Sun Jun 20, 2004 9:00 pm
This topic started in the autoimmune section with a post by OddDuck (Deb) and her research and theories are now posted as a headline article here on ThisIsMS..
My post is just some more info on Desipramine and its relationship to MS..
-------------------------------------------------------------------------------
First let me say thanks to Deb for all her research and non conformist thinking to provide everyone with this great overview and well thoughtout and prepared documentation.
One thing is certain, until someone else steps forward, Deb is so far the only example of the interaction of Desipramine and someone with MS, and with that known, we are at the mathmatical conjecture "if one in a given, two is an absolute", so hopefully that other "absolute" will appear and add more to this extremely interesting subject.
I read Debs information several times, and I found it to be very conclusive in all areas as per specifics of her purpose, and as it is obvious she has spent a great deal of time in checking and rechecking all aspects of Desipramine, perhaps first it would be good to see how it is decribed:
Desipramine : Brand Names Norpramin, Pertofrane
http://www.mentalhealth.com/drug/p30-n03.html
As can be seen on this page there are several areas of specific concern, everyone should read these areas thouroughly. But as to the concerns, the actual negative aspects are not truely stated as per volume of dosage.
DESIPRAMINE HYDROCHLORIDE
http://www.rxlist.com/cgi/generic2/desipram.htm
-----------------------------------------------------
While looking over the chemical makeup of DESIPRAMINE, I noticed the word Monohydrochloride, with a definition here:
http://www.online-medical-dictionary.or ... rochloride
Quinpirole Monohydrochloride
A dopamine D2/D3 receptor agonist.
----------------------------------------
Pertaining to the use of Desipramine ( or should I say lack of) in regards to MS, at this site, under Pain/Altered Sensation (Dysaesthesia) you will see Desipramine listed..
http://www.mult-sclerosis.org/mstreatments.html
-------------------------------------------------
Once again we find Desipramine mentioned in an article on MS, it is mentioned in the area of pain relief:
MS usually causes severe pain in over 60% of patients. The pain itself is a strong stressor instigating flare-up (relapse) of MS. Treatment with anticonvulsants such as Tegretol (non-generic), Klonopin® (non-generic), and Depakote help in the management of severe pain. Analgesic antidepressant treatment with Trazodone or Desipramine (not Amitriptyline), opioid antagonists, Tramadol (Ultram) are the minimum requirements.
http://www.rsdrx.com/Multiple%20Sclerosis.htm
---------------------------------------------
And here as to be used for emotional areas..
Emotional disorders (depression, mood swings) 25-50% amitriptyline (Elavil)
desipramine (Norparmin, Pertofrane) imipramine (Tofranil)
http://imaginis.com/multiple-sclerosis/ ... for-ms.asp
----------------------------------------
And here again for the emotional aspects :
... The authors con- cluded that desipramine is beneficial for MS patients experi- encing serious depression, but the ... Symptomatic therapy of multiple sclerosis.
Note:** The below link will take you to a pdf document..
http://www.cpa-apc.org/Publications/Arc ... odgers.pdf
--------------------------------------------
So, with all these references to desipramine and MS in regards to pain & psycological, one would assume that at sometime,somewhere, it would have been used, maybe not.
We know what desipramine has done for Deb, so now it would be wonderful to find others and see what thier experiance was, I suspect, and this is purely my thoughts, that perhaps due to the stated side effects and other negatives, perhaps Doctors shyed away from it, or it was used and never looked at as what was "actually" helping, as it was used for other aspects of MS..
----------------------------------
Deb, Thank you for your hard work, you are a great example of what needs to be done in situations like this, I am so glad you stepped up and posted this, and we can hope you have set an example for everyone to not hesitate to let everyone know about "anything" that might be of help to others in dealing with this Disease or any disease.
Philip
My post is just some more info on Desipramine and its relationship to MS..
-------------------------------------------------------------------------------
First let me say thanks to Deb for all her research and non conformist thinking to provide everyone with this great overview and well thoughtout and prepared documentation.
One thing is certain, until someone else steps forward, Deb is so far the only example of the interaction of Desipramine and someone with MS, and with that known, we are at the mathmatical conjecture "if one in a given, two is an absolute", so hopefully that other "absolute" will appear and add more to this extremely interesting subject.
I read Debs information several times, and I found it to be very conclusive in all areas as per specifics of her purpose, and as it is obvious she has spent a great deal of time in checking and rechecking all aspects of Desipramine, perhaps first it would be good to see how it is decribed:
Desipramine : Brand Names Norpramin, Pertofrane
http://www.mentalhealth.com/drug/p30-n03.html
As can be seen on this page there are several areas of specific concern, everyone should read these areas thouroughly. But as to the concerns, the actual negative aspects are not truely stated as per volume of dosage.
DESIPRAMINE HYDROCHLORIDE
http://www.rxlist.com/cgi/generic2/desipram.htm
-----------------------------------------------------
While looking over the chemical makeup of DESIPRAMINE, I noticed the word Monohydrochloride, with a definition here:
http://www.online-medical-dictionary.or ... rochloride
Quinpirole Monohydrochloride
A dopamine D2/D3 receptor agonist.
----------------------------------------
Pertaining to the use of Desipramine ( or should I say lack of) in regards to MS, at this site, under Pain/Altered Sensation (Dysaesthesia) you will see Desipramine listed..
http://www.mult-sclerosis.org/mstreatments.html
-------------------------------------------------
Once again we find Desipramine mentioned in an article on MS, it is mentioned in the area of pain relief:
MS usually causes severe pain in over 60% of patients. The pain itself is a strong stressor instigating flare-up (relapse) of MS. Treatment with anticonvulsants such as Tegretol (non-generic), Klonopin® (non-generic), and Depakote help in the management of severe pain. Analgesic antidepressant treatment with Trazodone or Desipramine (not Amitriptyline), opioid antagonists, Tramadol (Ultram) are the minimum requirements.
http://www.rsdrx.com/Multiple%20Sclerosis.htm
---------------------------------------------
And here as to be used for emotional areas..
Emotional disorders (depression, mood swings) 25-50% amitriptyline (Elavil)
desipramine (Norparmin, Pertofrane) imipramine (Tofranil)
http://imaginis.com/multiple-sclerosis/ ... for-ms.asp
----------------------------------------
And here again for the emotional aspects :
... The authors con- cluded that desipramine is beneficial for MS patients experi- encing serious depression, but the ... Symptomatic therapy of multiple sclerosis.
Note:** The below link will take you to a pdf document..
http://www.cpa-apc.org/Publications/Arc ... odgers.pdf
--------------------------------------------
So, with all these references to desipramine and MS in regards to pain & psycological, one would assume that at sometime,somewhere, it would have been used, maybe not.
We know what desipramine has done for Deb, so now it would be wonderful to find others and see what thier experiance was, I suspect, and this is purely my thoughts, that perhaps due to the stated side effects and other negatives, perhaps Doctors shyed away from it, or it was used and never looked at as what was "actually" helping, as it was used for other aspects of MS..
----------------------------------
Deb, Thank you for your hard work, you are a great example of what needs to be done in situations like this, I am so glad you stepped up and posted this, and we can hope you have set an example for everyone to not hesitate to let everyone know about "anything" that might be of help to others in dealing with this Disease or any disease.
Philip