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Could Cannabis based drugs inhibit the development of MS?
Posted: Mon Sep 23, 2013 4:54 am
by MSUK
Therapeutic Potential of a Novel Cannabinoid Agent CB52 in the Mouse Model ofExperimental Autoimmune Encephalomyelitis.
Abstract
Multiple Sclerosis (MS) is a demyelinating disease which causes inflammation, demyelination, and axonal injury. Currently, there is no cure for the disease. The endocannabinoid system has recently emerged as a promising therapeutic target for MS....... Read More -
http://www.ms-uk.org/cannabisresearch
Re: Could Cannabis based drugs inhibit the development of MS
Posted: Mon Sep 23, 2013 10:00 am
by HarryZ
squiffy2 wrote:Therapeutic Potential of a Novel Cannabinoid Agent CB52 in the Mouse Model ofExperimental Autoimmune Encephalomyelitis.
Abstract
Multiple Sclerosis (MS) is a demyelinating disease which causes inflammation, demyelination, and axonal injury. Currently, there is no cure for the disease. The endocannabinoid system has recently emerged as a promising therapeutic target for MS....... Read More -
http://www.ms-uk.org/cannabisresearch
Science usually wins when it comes to battles with politics but in the case of using MJ for medical purposes (MS) it has been a long, slow process. It seems every month they are discovering more and more benefits with MJ with use on MS patients but it's going to take a lot more convincing and research to get the approvals needed, especially in the US.
Harry
Re: Could Cannabis based drugs inhibit the development of MS
Posted: Thu Sep 26, 2013 5:04 pm
by Tif
Thanks for posting info, very interesting. I have found that the capsules/edibles absolutely,positively help. They annihilate all spasms (in my case). I had severe leg and knee pain, not when I take my med's(capsule). They are doing something that improves my balance and overall strength. I hope others try mmj and post their results, you will be amazed.
Tif
Re: Could Cannabis based drugs inhibit the development of MS
Posted: Fri Sep 27, 2013 5:23 am
by HappyPoet
Using primary cultures of mature oligodendrocytes, we tested the effect of a novel synthetic cannabinoid CB-52 on oligodendrocyte toxicity induced by peroxynitrite, the primary toxic species released by microglia. ... Using experimental autoimmune encephalomyelitis (EAE), an animal model of MS, we found that CB-52 reduces microglia activation, nitrotyrosine formation, T cell infiltration, oligodendrocyte toxicity, myelin loss and axonal damage in the mouse spinal cord white matter and alleviates the clinical scores when given either before or after disease onset.
Of course! A
synthetic cannabinoid -- big pharma can patent this 'novel' cannabinoid and charge patients $60,000/year as opposed to the use of free, natural cannabinoids of which there are hundreds, many of which haven't been investigated yet and sadly, probably won't be investigated.
Of course! EAE again. And again and again and again...