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WHAT DO YOU THINK ABOUT THIS?

http://www.ncbi.nlm.nih.gov/pubmed/23691965
http://communities.washingtontimes.com/ ... -not-mind/

ANY COINCIDENCE?

ton wrote:WHAT DO YOU THINK ABOUT THIS?

http://www.ncbi.nlm.nih.gov/pubmed/23691965
http://communities.washingtontimes.com/ ... -not-mind/

ANY COINCIDENCE?

From the results section:

Arteriole venule shunts were seen in 14/23 control patients and 18/24 fibromyalgia patients

I don't have access to the article, so I can't comment on the data regarding peptidergic sensory innervation, but I find it dubious that the quantitative results aren't in the abstract. The data should be in the abstract for a straight-forward study such as this

Anyone with institution based access to pubmed mind posting the data?

-C

I think what the researchers are saying is that excessive innervation to the AVS is the source of fibromyalgia pain. Here is the conclusion from the study.

"The excessive sensory innervation to the glabrous skin AVS is a likely source of severe pain and tenderness in the hands of FM patients..."

The underlying disease pathway in fibromyalgia is the same as in MS. Fibromyalgia and MS patients lack the enzymes that digest proteins and dietary DNA. One of the functions of these enzymes is to bind and transport vitamin B12. Just as in MS, research confirms patients with fibromyalgia are unable to properly metabolize vitamin B12. A vitamin B12 deficiency increases nerve growth factor. Here is a study on this.

http://www.ncbi.nlm.nih.gov/pubmed/16352395

Excess nerve growth factor leads to excessive sensory innervation. Here is a study on this.

http://www.jneurosci.org/content/19/19/8509.full.pdf

Here is a study on the increased concentrations of nerve growth factor in fibromyalgia.

J Rheumatol. 1999 Jul;26(7):1564-9.
Increased concentrations of nerve growth factor in cerebrospinal fluid of patients with fibromyalgia.
Giovengo SL, Russell IJ, Larson AA.

"The findings of increased concentrations of NGF in patients with FM suggest a central mechanism, involving abnormalities in neuropeptides such as NGF, may be a factor in the pathogenesis of FM."

Due to an inability to properly metabolize vitamin B12, patients with MS also have increased levels of nerve growth factor.
http://www.ncbi.nlm.nih.gov/pubmed/1480330



To say this finding solves the fibromyalgia puzzle would be like saying it solves the MS puzzle. There are many additional valid scientific findings (and symptoms) in fibromyalgia that have nothing to do with excessive sensory innervation to the AVS.

I posted a great deal on the underlying disease process of MS on this thread.

http://www.thisisms.com/forum/general-d ... 22806.html

Annesse wrote:I think what the researchers are saying is that excessive innervation to the AVS is the source of fibromyalgia pain. Here is the conclusion from the study

Right...I understand. I just wanted to see the actual data. What if the odds ratio isn't very impressive?

To say this finding solves the fibromyalgia puzzle would be like saying it solves the MS puzzle. There are many additional valid scientific findings (and symptoms) in fibromyalgia that have nothing to do with excessive sensory innervation to the AVS.

I tend to agree with you

Right, here a few more research findings that would need to be explained.
• Lack of essential amino acids
• Low serotonin
• Low melatonin
• Low dopamine
• Low adrenal function
• Brain grey matter loss
• Hypothyroidism
• Mitochrondrial dysfunction
• Low ATP
• Reduced CoQ10
• Low carnitine
• Low glutathione
• Low serum ferritin
• Low muscle oxygenation
• Restless legs syndrome
• Spinal cord degeneration
• Carpal tunnel syndrome
• Low vitamin B12
• Autonomic nervous system dysfunction (dysautonomia)
• Postural orthostatic tachycardia syndrome (POTS)
• Overactive bladder
• Dry eyes and mouth
• Sleep apnea
• Migraines and headaches
• Elevated substance P
• Raynaud’s phenomenon
• Low intracellular magnesium
• Elevated homocysteine
• Decreased levels of collagen cross-linking
• Temporomandibular joint disorder (TMJ)
Mitral valve prolapse
• Hypermobility
• Excess nitric oxide
• Endometriosis
• Increased risk of cancer
• Elevated tumor necrosis factor (TNF)
• Allodynia
• Excessive daytime sleepiness
• Chronic urticaria (hives)
• Allergies
• Inflammatory bowel disease
• Low GABA
• Anxiety
• Association with ADHD
• Sound sensitivity
• Severe premenstrual syndrome
• Elevated glutamate
• Depression
• Bipolar disorder
• Increased risk of suicide
• Irritable bowel syndrome
• Interstitial cystitis
• Inflammation of the fascia
• Increased kynurenine pathway activity
• Low growth hormone secretion
• Low somatomedin C
• Low endorphins
• Comorbidity with rheumatoid arthritis
• Osteoporosis
• Low calcium
• Low vitamin D
• Low zinc
• Low stomach acid
• Small intestine bacterial overgrowth (SIBO)
• Increased intestinal permeability
• Multiple chemical sensitivity
• Low cortisol
• Low estrogen
• Low DHEA
• Low testosterone
• Comorbidity with lupus
• Abnormal proteins

Then you should be looking at Megalin and Cubilin.

Regards

From the list of Annesse in the above posting, I recognise many things.
I have made a selection of issues that are in some way related through the endocrine system (see below).
The selection of issues points to a dysfunction of the critical HPA axis.
That is why we need good endocrinologists with an open mind to look at our disease.

See also
http://syontix.com/the-gut-brain-axis-h ... enal-axis/
http://www.thisisms.com/forum/general-d ... 8-480.html


• Low serotonin
• Low melatonin
• Low adrenal function
• Brain grey matter loss
• Hypothyroidism
• Mitochrondrial dysfunction
• Low ATP
• Reduced CoQ10
• Low carnitine
• Low muscle oxygenation
• Restless legs syndrome
• Spinal cord degeneration
• Low vitamin B12
• Autonomic nervous system dysfunction (dysautonomia)
• Overactive bladder
• Dry eyes and mouth
• Low intracellular magnesium
• Allergies
• Inflammatory bowel disease
• Association with ADHD
• Elevated glutamate
• Irritable bowel syndrome
• Low growth hormone secretion
• Comorbidity with rheumatoid arthritis
• Osteoporosis
• Low calcium
• Low vitamin D
• Low zinc
• Low stomach acid
• Small intestine bacterial overgrowth (SIBO)
• Increased intestinal permeability
• Low cortisol
• Low estrogen
• Low DHEA
• Low testosterone
• Comorbidity with lupus
• Abnormal proteins

Just as in MS, everything on the list can be traced directly back to the missing enzymes protease and DNase 1. In fact, recent very definitive cerebrospinal fluid studies confirm the involvement of protease in fibromyalgia. The symptoms and scientific findings of fibromyalgia are the same as in MS because the underlying disease process is the same.

For instance, take the first thing on the list; low serotonin. Patients with MS also lack serotonin. The reason is, both fibromyalgia and MS patients lack the essential amino acid serotonin is derived from; tryptophan.

The enzymes "protease" break down dietary proteins and release essential amino acids.



The following study confirms that fibromyalgia (FM) patients have significantly lower levels of serotonin.

Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population.Wolfe, F., I.J. Russell, G. Vipraio, K. Ross, J. Anderson. 1997.
J Rheumatol 24(3):555-9.

“Serum serotonin levels are significantly lower in persons with FM compared to those without FM…”


Serotonin is derived from the essential amino acid tyrptophan. In the following study published in the Journal of Rheumatology researchers found that fibromyalgia patients were deficient in tryptophan.

Plasma tryptophan and other amino acids in primary fibromyalgia: a controlled study.
Yunus M.B., J.W. Dailey, J.C. Aldag, A.T. Masi, P.C. Jobe. 1992. J Rheumatol Jan;19(1):90-4.

“Transport ratio of tryptophan was found to be significantly decreased in PF compared with the control group…Plasma tryptophan level was lower in PF than in healthy controls…Additionally, plasma histidine levels were found to be significantly lower in patients with PF than in controls.”