This Is MS Multiple Sclerosis Knowledge & Support Community

HI FRIENDAS A Phase1 trails of a new treatment to reset the immune system of m.s patients shows the therapy is safe and highly effective.
please read more http://www.healthline.com/health-news/m ... cks-060513
regard
seeva

seeva wrote:HI FRIENDAS A Phase1 trails of a new treatment to reset the immune system of m.s patients shows the therapy is safe and highly effective.
please read more http://www.healthline.com/health-news/m ... cks-060513
regard
seeva

I've said it before many times...nobody has been able to prove that MS is an auto-immune disease and some researchers have stated they believe that the patient's immune system is only reacting to another unknown event which is triggering the immune system to respond in a normal manner.

Now if this procedure does indeed prevent the immune system from causing further damage to the MS patient that would be great. Whether it does anything to stop that initial attack process is unknown but at least the severity and number of attacks might be curtailed.

But you can expect our MS drug making companies not to sit idly by and have a process interfere with their cash cow. Certainly makes for interesting months ahead.

Harry

"The results showed that the therapy was safe and reduced the patients’ immune system attacks on myelin by as much as 50 to 75 percent."

This article is just painful to read. The article doesn't state the outcome measure. Are they referring to gad+ lesions, new/enlarging T2 lesions, clinical relapses? What do you mean by "as much as 50-75%"? What is the average size of effect?

If you have one patient that had no relapses, you can call it "as much as 100% reduction in relapses"

Sheesh

centenarian100 wrote:"The results showed that the therapy was safe and reduced the patients’ immune system attacks on myelin by as much as 50 to 75 percent."

This article is just painful to read. The article doesn't state the outcome measure. Are they referring to gad+ lesions, new/enlarging T2 lesions, clinical relapses? What do you mean by "as much as 50-75%"? What is the average size of effect?

If you have one patient that had no relapses, you can call it "as much as 100% reduction in relapses"

Sheesh

Phase 1 and 2 studies more often than not don't give a lot of detailed information. They are mostly done to test for side effects and ensure that patients can tolerate the medication. The nitty gritty numbers come with Phase 3 trials. And those usually take 2 years to complete after being approved to start.

HarryZ wrote:Phase 1 and 2 studies more often than not don't give a lot of detailed information. They are mostly done to test for side effects and ensure that patients can tolerate the medication. The nitty gritty numbers come with Phase 3 trials. And those usually take 2 years to complete after being approved to start.

Phase 1 studies are mainly for safety, but the article makes claims about efficacy, and if they are going to make such claims, they should state the data explicitly.

centenarian100 wrote:"The results showed that the therapy was safe and reduced the patients’ immune system attacks on myelin by as much as 50 to 75 percent."

This article is just painful to read. The article doesn't state the outcome measure. Are they referring to gad+ lesions, new/enlarging T2 lesions, clinical relapses? What do you mean by "as much as 50-75%"? What is the average size of effect?

If you have one patient that had no relapses, you can call it "as much as 100% reduction in relapses"

Sheesh

Required reading for Big Pharma execs: http://en.wikipedia.org/wiki/How_to_Lie_with_Statistics

PointsNorth wrote:Required reading for Big Pharma execs: http://en.wikipedia.org/wiki/How_to_Lie_with_Statistics

Haha

nice username by the way

Phase 1 studies are mainly for safety, but the article makes claims about efficacy, and if they are going to make such claims, they should state the data explicitly.

It's called throwing out a carrot to the public in order to create interest!!

Over the years I've attended presentations sponsored by the MS drug makers where they brought out the fancy stat charts to show how wonderful their medication was helping MS patients. When you sifted through all the rhetoric, you soon realized the slick marketing behind it all.

HarryZ wrote:It's called throwing out a carrot to the public in order to create interest!!

Over the years I've attended presentations sponsored by the MS drug makers where they brought out the fancy stat charts to show how wonderful their medication was helping MS patients. When you sifted through all the rhetoric, you soon realized the slick marketing behind it all.

Marketing works. They actually convinced me that I need a shiny rock to be happy.

centenarian100 wrote:

HarryZ wrote:It's called throwing out a carrot to the public in order to create interest!!

Over the years I've attended presentations sponsored by the MS drug makers where they brought out the fancy stat charts to show how wonderful their medication was helping MS patients. When you sifted through all the rhetoric, you soon realized the slick marketing behind it all.

Marketing works. They actually convinced me that I need a shiny rock to be happy.

There you go!!! Just don't give any of those CRAB drugs to that nice rock