Accidental discovery regrows Myelin
Posted: Tue Jul 25, 2006 8:08 am
I saw this in our local paper (Hamilton, Ontario), it doesn't mention MS but does sound interesting. So I thought I would pass it along. The McMaster mentioned is McMaster University Medical Centre
Paralyzed rats walk after Mac treatment
Researchers' feat could help humans
By Joanna Frketich
The Hamilton Spectator
(Jul 24, 2006)
McMaster researchers are a step closer to curing paralysis after accidentally discovering how to regrow nerve casings required for the brain and body to communicate.
Paralyzed rats walked again after Dr. Shucui Jiang used a naturally-occurring compound called guanosine, found in many foods such as fish, to regenerate a protein and fatty substance called myelin that forms an insulating layer around nerves.
This myelin sheath allows rapid transmission of signals between the body and the brain. If the myelin is damaged, the messages are disrupted so finding ways to regrow the special insulation is crucial to curing spinal chord injuries.
"The animals were moving much better and walking much better," Jiang said.
It's a major breakthrough for Jiang and her colleague Dr. Michel Rathbone, who have already successfully regenerated nerves in the spine by transplanting cells from the intestine into the spinal cord.
"We're very excited," Jiang said. "We expect this will improve the chronically injured patients' function. Although, we don't know to which extent."
Human studies could begin within two years if Jiang is able to find enough funding.
She's part of the Hamilton NeuroRestorative Group (NRG) being announced tonight that is desperately searching for money from government, private donors or charities to stay afloat.
The NRG brings together spinal cord researchers at McMaster from a wide variety of fields such as neurology, rehabilitation, kinesiology, plastic surgery, cardiac surgery and basic science.
For the first time, they are collaborating with the hope that each of them holds a piece of the puzzle that will eventually lead to paraplegics and quadriplegics walking again.
"It's encouraging (that) a group of clinicians and scientists, who would normally never talk to each other, talk to each other," Rathbone said. "Normally we have solitudes."
The group, which started meeting in the fall, has already had progress discovering they had information to prove cancer patients who get spinal chord injuries from tumours improve their movement, overall health, psychologically well-being and even prolong their lives by exercising.
But continuing Hamilton's leading spinal cord research is in jeopardy unless the NRG gets at least $1 million a year to keep going. It is getting some help from the Golden Horseshoe Marathon.
The team raises money while wheeling from Niagara Falls to Toronto over five days in September.
They do a full 42.5 kilometres a day using everyday wheelchairs powered solely by their arms and upper body.
Athletes will cover a total of 212.5 kilometres.
But even if they make their goal of $500,000, it won't be enough.
"One generous sponsor would turn the tables," Rathbone said.
Paralyzed rats walk after Mac treatment
Researchers' feat could help humans
By Joanna Frketich
The Hamilton Spectator
(Jul 24, 2006)
McMaster researchers are a step closer to curing paralysis after accidentally discovering how to regrow nerve casings required for the brain and body to communicate.
Paralyzed rats walked again after Dr. Shucui Jiang used a naturally-occurring compound called guanosine, found in many foods such as fish, to regenerate a protein and fatty substance called myelin that forms an insulating layer around nerves.
This myelin sheath allows rapid transmission of signals between the body and the brain. If the myelin is damaged, the messages are disrupted so finding ways to regrow the special insulation is crucial to curing spinal chord injuries.
"The animals were moving much better and walking much better," Jiang said.
It's a major breakthrough for Jiang and her colleague Dr. Michel Rathbone, who have already successfully regenerated nerves in the spine by transplanting cells from the intestine into the spinal cord.
"We're very excited," Jiang said. "We expect this will improve the chronically injured patients' function. Although, we don't know to which extent."
Human studies could begin within two years if Jiang is able to find enough funding.
She's part of the Hamilton NeuroRestorative Group (NRG) being announced tonight that is desperately searching for money from government, private donors or charities to stay afloat.
The NRG brings together spinal cord researchers at McMaster from a wide variety of fields such as neurology, rehabilitation, kinesiology, plastic surgery, cardiac surgery and basic science.
For the first time, they are collaborating with the hope that each of them holds a piece of the puzzle that will eventually lead to paraplegics and quadriplegics walking again.
"It's encouraging (that) a group of clinicians and scientists, who would normally never talk to each other, talk to each other," Rathbone said. "Normally we have solitudes."
The group, which started meeting in the fall, has already had progress discovering they had information to prove cancer patients who get spinal chord injuries from tumours improve their movement, overall health, psychologically well-being and even prolong their lives by exercising.
But continuing Hamilton's leading spinal cord research is in jeopardy unless the NRG gets at least $1 million a year to keep going. It is getting some help from the Golden Horseshoe Marathon.
The team raises money while wheeling from Niagara Falls to Toronto over five days in September.
They do a full 42.5 kilometres a day using everyday wheelchairs powered solely by their arms and upper body.
Athletes will cover a total of 212.5 kilometres.
But even if they make their goal of $500,000, it won't be enough.
"One generous sponsor would turn the tables," Rathbone said.