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Protein that inhibits the development of autoimmune disease

PostPosted: Thu Aug 17, 2017 12:18 am
Protein that inhibits the development of #autoimmune diseases discovered

Scientists have identified the elementary function of the protein, Caveolin-1 in the plasma membrane of B-cells, which prevents the development of autoimmune conditions...Read more -

Re: Protein that inhibits the development of autoimmune dise

PostPosted: Thu Aug 17, 2017 4:06 am
by NHE
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance
Nature Immunology (2017) doi:10.1038/ni.3813

    Caveolin-1 (Cav1) regulates the nanoscale organization and compartmentalization of the plasma membrane. Here we found that Cav1 controlled the distribution of nanoclusters of isotype-specific B cell antigen receptors (BCRs) on the surface of B cells. In mature B cells stimulated with antigen, the immunoglobulin M BCR (IgM-BCR) gained access to lipid domains enriched for GM1 glycolipids, by a process that was dependent on the phosphorylation of Cav1 by the Src family of kinases. Antigen-induced reorganization of nanoclusters of IgM-BCRs and IgD-BCRs regulated BCR signaling in vivo. In immature Cav1-deficient B cells, altered nanoscale organization of IgM-BCRs resulted in a failure of receptor editing and a skewed repertoire of B cells expressing immunoglobulin-μ heavy chains with hallmarks of poly- and auto-reactivity, which ultimately led to autoimmunity in mice. Thus, Cav1 emerges as a cell-intrinsic regulator that prevents B cell–induced autoimmunity by means of its role in plasma-membrane organization.