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Microglia (resident cells of the brain) are activated in MS. They produce NAWM (normal appearing white matter) and the MS lesions and are considered the root problem in MS. Microglia activation can be observed using PET (Positron emision tomography, see for example here).

The following article says that current DMTs (disease modifying therapies) do not alter the microglial activation which is the root problem. They only reduce the symptoms. Maybe this is the reason why they all fail in PPMS.

Neuroinflammation following disease modifying therapy in multiple sclerosis.

Source:http://www.jns-journal.com/article/S002 ... X/fulltext

Conclusions

The current results indicate that microglial activation may proceed in the entire brain of clinically stable MS patients even after receiving DMT.

It is well known in medicine that vitamin D inhibits microglial activation.

tzootsi wrote:It is well known in medicine that vitamin D inhibits microglial activation.

Well. It could be. But maybe to inhibit microglial activation is wrong.

This recent article says that microglial activation is directly produced by EBV infection. They have found the EBV DNA in the active lesions. If this is the case, to inhibit microglial activation could be even worse:

https://www.researchgate.net/profile/Ja ... sis-Lesion