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Accelerated Cure Project

Posted: Wed Oct 25, 2006 10:37 am
by bromley

blood samples

Posted: Wed Oct 25, 2006 11:15 am
by gwa
I am liking the fact that they are wanting blood and tissue samples from living patients.

Too many tissue research is done postmortem when the person can't answer questions.

gwa

Posted: Wed Oct 25, 2006 12:13 pm
by marcstck
I'm taking part in this. Have an 80 page survey to fill out (mostly on genetic background), this Friday I go in to have blood drawn and spend two hours being interviewed by a research associate. I became involved though my neurologist's office...

relatives

Posted: Thu Oct 26, 2006 10:51 am
by gwa
marcstock,

Are you the only person in your familywith MS?

gwa

Posted: Thu Oct 26, 2006 11:04 am
by marcstck
Yes, but my Mom came down with type 1 diabetes when she was pregnant with me. Could there be one pathogen triggering both diseases? She has also developed Parkinson's, later in life...

ACP

Posted: Thu Oct 26, 2006 11:47 am
by Muu
This makes such perfect sense.
Muu

Posted: Sat Oct 28, 2006 11:27 am
by ljm
I really like the idea of accelerated cure taking on one, big project that can help multiple research endeavors, its an incredible contribution.

Posted: Sat Oct 28, 2006 1:06 pm
by bromley
GWA wrote:
I am liking the fact that they are wanting blood and tissue samples from living patients.
I wouldn't like to meet you on Halloween!

GWA wrote:
Too many tissue research is done postmortem when the person can't answer questions.
I have an aunt who's a psychic if you think that might help? What questions would you like them to answer?

Ian

Knowledge from "Beyond'

Posted: Sat Oct 28, 2006 2:16 pm
by gwa
Ian,

Please ask your aunt to talk to Richard Pryor (dead American comic that had MS) and ask him to find out what causes MS.

He should be in a place now that has all the answers. :wink:

gwa

richard pryor and ms

Posted: Sat Oct 28, 2006 4:20 pm
by jimmylegs
i searched on "cocaine oxidative stress" in google. looks like a bunch of familiar terminology doesn't it!

http://cat.inist.fr/?aModele=afficheN&cpsidt=14680131
The objective of the present study was to verify if immunosuppression caused by cocaine (CO) can be mediated, at least in part, by increased formation of oxidative metabolites and reactive oxygen species (ROS) in rat. Pharmacokinetics of cocaine and its metabolites, cell-mediated immune function and cytokines production, biomarkers of cell redox state maintenance and lipidic peroxidation, and variations of activity in the enzymatic systems involved in cell antioxidant defence were measured in spleen of Wistar rats acutely and chronically treated with cocaine. C[max], AUC, and 1[1]/2 of norcocaine (NC) significantly increased after chronic exposure to cocaine while kinetic parameters of benzoylecgonine (BE) significantly decreased. A decrease in cultured T-lymphocytes proliferation and natural killer (NK) cell activity, a high increase of immunosuppressive cytokines and a switch from Th1-type cytokines to Th2-type cytokines together with an unbalance toward anti-inflammatory cytokines recovered within 4 h after acute treatment while subsisted for 14 days after chronic treatment. A significant increase in ascorbic acid (AA), reduced glutathione and glutathione reductase (GR) with a simultaneous decrease in oxidized glutathione were observed in the first hours after acute administration. Conversely, the increase in oxidized glutathione and malondialdehyde (MDA) production and the simultaneous depletion of reduced glutathione and ascorbic acid persisted at least 24 h after chronic cocaine treatment as well as the increase in the activities of glutathione reductase, glutathione peroxidase (GPx) and superoxide dismutase (SOD). The results suggest that chronic cocaine administration affects cellular enzyme and non-enzyme-mediated antioxidant defence systems and promotes immunotoxicity in rat. Cocaine N-oxidative metabolism may be an indirect contributor, via oxidative stress.