Posted: Wed Nov 22, 2006 8:11 am
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I just want to be clear - I'm not being a naysayer. I really hope and pray that this is a real deal. I personally dislike the way folks critisize things without offering an alternative. In this case, I'm just wanting clarity about that the therapy has done. I realize that we're not going to get to see the data and I think folks ought to get a shot as seeing it if they're going to participate in the study. Have a Great Thanksgiving everyone! napayLyon wrote:I've got the same concerns napay but it seems that we are going to have to wait and see.
Bob
Going from MEMORY. In the trial where the 90% was quoted, one person had one relapse. I dont know how many people or how long the trial was for. ... see link for abstract ... It would also appear that the relapse occured in the lower dosage group.notasperfectasyou wrote:ok. I'm a numbers guy. what does this really mean? It sounds like a comparison to me. They are measuring relapse reduction - is that number of exaserbations compared to prior year? Given what this therapy is saying it does, I'd prefer to see something like 90% of patients had NO relapses. The implication is that folks had exaserbations, it's just that they had fewer of them.
Corticosteroids, such as prednisone, induce apoptosis in lymphocytes. That is, they induce the white blood cells to die off. It's likely that this reduces the number of myelin reactive T-cells to such a low number that they are difficult to isolate.Lyon wrote:The nurse did mention in passing that having ANY residual steroids in your blood before MRTC testing had been greatly reducing success in isolating MRTC's which they considered good reason to strictly adhere to the no steroid use in the previous 60 (90?) days. I thought that was an interesting tidbit and it made me wonder if steroids mask MRTCs or eliminate them from the blood somehow?
Yes, I think you're right Bob. I'll call in the morning.Lyon wrote: I imagine isolating the T cells is expensive enough that they want the odds of success to be as good as possible.