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Immune and nervous system cells talk to each other

PostPosted: Tue Aug 21, 2007 11:35 am
by TwistedHelix
Signalling between cells is vital for correct functioning, but I didn't realise that the immune system and nervous system talked to each other quite so much:

Trends Immunol. 2007 Aug 3;
Franco R, Pacheco R, Lluis C, Ahern GP, O''connell PJ
Discuss | category: Immunology

Initially, the idea that neurotransmitters could serve as immunomodulators emerged with the discovery that their release and diffusion from nervous tissue could lead to signaling through lymphocyte cell-surface receptors and the modulation of immune function. It is now evident that neurotransmitters can also be released from leukocytes and act as autocrine or paracrine modulators. Here, we review the data indicating that leukocytes synthesize and release 'neurotransmitters' and we also discuss the diverse effects that these compounds exert in a variety of immune cells. The role of neurotransmitters in immune-related diseases is also reviewed succinctly. Current and future developments in understanding the cross-talk between the immune and nervous systems will probably identify new avenues for treating immune-mediated diseases using agonists or antagonists of neurotransmitter receptors


PostPosted: Tue Aug 21, 2007 2:13 pm
by notasperfectasyou
Thanks for putting this up.

I found a link to the abstract ... 23Articles)&_cdi=6627&_sort=d&_docanchor=&view=c&_ct=6&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7a5af9c00dc3d309ceb693e7c3626d5f#

I couldn't make a link with it, but it works if you cut and paste it. It drives me nuts that yagotta pay $30 to see it. napay

I speculate that they are talking about cytokines/genes etc.

PostPosted: Tue Aug 21, 2007 2:37 pm
by jimmylegs
it's not even up thru my school's subscription yet, title page has it in the list of "forthcoming articles"