Posted: Thu Sep 13, 2007 5:36 am
Not that we're entering forbidden territory but, under a different pretense, we are entering territory researchers have been struggling with for many years. "What starts (this phase of) the MS disease process and what drives it's continuance?"
When (not "if") we answer that on thisisms I'm in for an even split of the royalties. Not because I intend to have any meaningful input, but because I'm a nice guy and because I otherwise won't be able to afford to replace the shiny shirts Ian gives me so much grief about.
Long ago, cancer researchers realized an increased degree of success against terminal Leukemia by not only killing the cancerous cells in the blood but by killing and replacing the bone marrow which had gotten into the mode of creating those cancer cells.
Researchers were aware that the MS process involves aberrant white blood cells and at some point MS researchers, not knowing at what stage of the creation/replication process the aberrant MS were created/driven (I think) they assumed that, like leukemia, aberrant MS cells were created in the bone marrow and any hope to realize positive results against MS would also require eliminating all the white blood cells and the bone marrow.
Due in equal amounts to the fortunes of fate and researcher skills, it was found, or at this point "seems" to have been found that "only" eliminating the white blood cells to grow back (hopefully/seemingly) without the continuance of the MS process is actually far less risky for the patient and more effective than additionally killing and "re-seeding" the bone marrow.
What lessons might that taught us about what starts and continues the MS disease process? At this point I don't think it tells us anything with certainty about where or when the disease process starts, but "IF" long term Campath/HDC (Revimmune) results are seen, I think it obviously shows that the bone marrow isn't responsible for the continuance of the MS process and seems to invite us to focus our attention (I wish I knew more about this subject) to the thymus, where the white cells mature, and the meiosis (cell division) process.
Input welcome, but that's how the subject has always seemed to me.
Bob
When (not "if") we answer that on thisisms I'm in for an even split of the royalties. Not because I intend to have any meaningful input, but because I'm a nice guy and because I otherwise won't be able to afford to replace the shiny shirts Ian gives me so much grief about.
Long ago, cancer researchers realized an increased degree of success against terminal Leukemia by not only killing the cancerous cells in the blood but by killing and replacing the bone marrow which had gotten into the mode of creating those cancer cells.
Researchers were aware that the MS process involves aberrant white blood cells and at some point MS researchers, not knowing at what stage of the creation/replication process the aberrant MS were created/driven (I think) they assumed that, like leukemia, aberrant MS cells were created in the bone marrow and any hope to realize positive results against MS would also require eliminating all the white blood cells and the bone marrow.
Due in equal amounts to the fortunes of fate and researcher skills, it was found, or at this point "seems" to have been found that "only" eliminating the white blood cells to grow back (hopefully/seemingly) without the continuance of the MS process is actually far less risky for the patient and more effective than additionally killing and "re-seeding" the bone marrow.
What lessons might that taught us about what starts and continues the MS disease process? At this point I don't think it tells us anything with certainty about where or when the disease process starts, but "IF" long term Campath/HDC (Revimmune) results are seen, I think it obviously shows that the bone marrow isn't responsible for the continuance of the MS process and seems to invite us to focus our attention (I wish I knew more about this subject) to the thymus, where the white cells mature, and the meiosis (cell division) process.
Input welcome, but that's how the subject has always seemed to me.
Bob