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Of course, since I'm "into" the importance of plasticity, there is also the possibility that her MS and resulting damage continues ominously at a rate in which plasticity is able to it's job and keep her from noticing the damage as it accumulates.

this is so well put bob we are all under attack all the time it's just that when our own bodies can't keep up with the repairs we start to notice the disability. do u think bob that even though u take a drug that stops the severe attacks that some get the disease is still at work in a milder form which current mri's can't detect ?(the inflamation that is).

robbie,

Read the post by dignan about gray matter atrophy. It discusses how people with the progressive disease have more gray matter atrophy (shrinkage) than RRMS people and that lesions are not the major player once a person is out of the early stages.

You would need to get your brain weighed every once in a while instead of going through an MRI and looking for lesions to get a better idea of how much you have progressed.

gwa