Puberty age and MS risk
Posted: Sun Feb 01, 2009 9:43 am
This could go a long way to explaining why MS incidence is rising among women faster than men:
Age of puberty and the risk of multiple sclerosis: a population based study.
Eur J Neurol. 2008 Dec 23.
Ramagopalan SV, Valdar W, Criscuoli M, Deluca GC, Dyment DA, Orton SM, Yee IM, Ebers GC, Sadovnick AD; for the Canadian Collaborative Study Group*.
Wellcome Trust Centre for Human Genetics, and Department of Clinical Neurology, University of Oxford, Oxford, UK.
Background and purpose
Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. Given a potential role for sex hormones in MS, we have investigated whether or not the age of puberty influences the risk of developing MS in a population-based cohort.
Methods
We identified 5493 MS index cases and 1759 spousal controls with age of puberty information from the Canadian Collaborative Project on Genetic Susceptibility to MS. Age of puberty was compared between index cases and controls, and any effect of age of puberty on the age of onset of MS was also investigated.
Results
There were no significant differences between male index cases and controls with respect to age of puberty, P = 0.70. However, a significant difference was observed between female index cases and female controls, with average age of puberty being 12.4 and 12.6 years respectively, P = 0.00017, providing a relative risk decrease of 0.9 per year increase of age of puberty. There was no effect of the age of puberty on the age of MS onset in either sex.
Conclusions
Earlier age at menarche increases the risk of MS in women. Whether this association is a surrogate for a disease causative factor or directly involved in MS disease aetiology needs to be uncovered.
http://www.ncbi.nlm.nih.gov/pubmed/19170744
Age of puberty and the risk of multiple sclerosis: a population based study.
Eur J Neurol. 2008 Dec 23.
Ramagopalan SV, Valdar W, Criscuoli M, Deluca GC, Dyment DA, Orton SM, Yee IM, Ebers GC, Sadovnick AD; for the Canadian Collaborative Study Group*.
Wellcome Trust Centre for Human Genetics, and Department of Clinical Neurology, University of Oxford, Oxford, UK.
Background and purpose
Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. Given a potential role for sex hormones in MS, we have investigated whether or not the age of puberty influences the risk of developing MS in a population-based cohort.
Methods
We identified 5493 MS index cases and 1759 spousal controls with age of puberty information from the Canadian Collaborative Project on Genetic Susceptibility to MS. Age of puberty was compared between index cases and controls, and any effect of age of puberty on the age of onset of MS was also investigated.
Results
There were no significant differences between male index cases and controls with respect to age of puberty, P = 0.70. However, a significant difference was observed between female index cases and female controls, with average age of puberty being 12.4 and 12.6 years respectively, P = 0.00017, providing a relative risk decrease of 0.9 per year increase of age of puberty. There was no effect of the age of puberty on the age of MS onset in either sex.
Conclusions
Earlier age at menarche increases the risk of MS in women. Whether this association is a surrogate for a disease causative factor or directly involved in MS disease aetiology needs to be uncovered.
http://www.ncbi.nlm.nih.gov/pubmed/19170744