Page 1 of 1
Euphoria before attack
Posted: Fri Mar 06, 2009 10:09 pm
by LR1234
Hi
Has anyone noticed that they feel really good and well just before a relapse like a real feeling of euphoria? I have noticed this has happened to me a few times now.
I can't work out if its because I feel well I do more hence bringing on an attack or if it is a biological/chemical thing.
Any ideas?
Posted: Sat Mar 07, 2009 3:28 am
by Wonderfulworld
Hi LR1234
I have also noticed this..It's nearly like I'm hyper for a few days then a HUGE sudden crash in my energy.
Sometimes I feel it building up and if I don't go with the false energy I can avert the relapse a bit, but all you want to do is go wild with all the things you can't normally do.
I wonder what causes it....hmmm.
Posted: Sat Mar 07, 2009 3:36 am
by LR1234
I am glad I am not the only one! I definately get this feeling of being really full of enery and hyper and about 4/5 days later I get that massive crash. I also tried last time to avert it when I recognised the feeling but had no luck. I wonder if it is our immune system becoming active in some way.
L
Posted: Sat Mar 07, 2009 3:32 pm
by sou
Hi.
I can't seem to find the study right now, but our body increases the production of beta endorphin during relapse, perhaps attempting to prevent it. It could be that endorphin boost that makes you feel that way.
sou
Edit: I have found the study. Here it is:
http://archneur.ama-assn.org/cgi/reprint/57/8/1178.pdf
Conclusions: A reduction of BE levels was present in patients with clinically inactive MS. Treatment with IFN-b seems to induce an increase of this opioid in PBMCs of MS patients. The increase of BE concentration during a clinical relapse may represent a possible control mechanism aimed at counterbalancing the inflammatory phase of the disease.
Posted: Sun Mar 08, 2009 12:25 pm
by Wonderfulworld
Thanks for posting that sue, that is really fascinating.
Wish my system made more beta endorphins because when they do hit, I can do nearly everything I want to. But just wish I could avoid the relapse that comes with it nearly every time.
Posted: Sun Mar 08, 2009 1:06 pm
by LR1234
Me too!! If we can just work out what we have to do at the point the europhia hits perhaps we can avert the relapse.
Thanks for the info Sou
L x
Posted: Sun Mar 08, 2009 5:10 pm
by CureOrBust
Wonderfulworld wrote:Wish my system made more beta endorphins because when they do hit, I can do nearly everything I want to. But just wish I could avoid the relapse that comes with it nearly every time.
Have either of you tried LDN? this all sounds similar to its method of action.
I do not get the euphoria before an attack, because my trigger before an attack is a cold/flu, so I feel pretty rubbish leading into an attack. And LDN did not appear to work for me personally either.
Posted: Mon Mar 09, 2009 1:33 am
by Wonderfulworld
No Cure I've never tried LDN. Been too much of a sissy to come off DMD's - Rebif then Copaxone - mainly because my MS without DMD is aggressive, and because I've done very well on Copaxone. I would definitely try LDN if I ever have to stop Copaxone.
Posted: Mon Mar 09, 2009 3:39 am
by CureOrBust
I don't think LDN and Copaxone are contra-indicatory, so you would not have to stop the Copaxone. Others will know more, and I know some are on this combination already.
Posted: Mon Mar 09, 2009 3:47 am
by Loobie
I agree Cure. I think "Chrishasms" is doing that combo.
Posted: Mon Mar 09, 2009 4:07 am
by DIM
As copaxone isn't immunosupressive it doesn't interfere with LDN, they work much better together according to some people that takes them both!
Posted: Mon Mar 09, 2009 12:43 pm
by Wonderfulworld
Thanks DIM, Loobie and Cure, that's one to think about.
I have only heard of one other Irish MS'er taking LDN and it's not available easily here I don't think, might email her to ask about it.
Being a worrier with a PhD in worrying, I would worry that the two would interact in some bizarre way in just me out of all the world.
Posted: Mon Mar 09, 2009 11:53 pm
by DIM
Contact Dr Bob Lawrence, he will prescribe it and arrange the shipping, he is PwPPMS and stable for more than 15 years only with LDN, BBD and supplements, you can find contact info at
www.ldnresearchtrust.org:
bob.lawrence@ntlworld.com
Good luck
Posted: Tue Mar 10, 2009 1:29 am
by LR1234
Thanks I will send him an e-mail
L x
Posted: Thu Apr 23, 2009 2:11 pm
by LR1234
Just thought I would bump this topic just to see if anyone else feels really good just before a relapse....(or feeling really bad)